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This happened around 3 a.m. on the Eastex Freeway at North Loop 610.
A woman was driving south in the northbound lanes of the freeway when she crashed into the family’s vehicle, Houston police said.
The reverse driver was also killed in the crash.
A mother, father and two other young children were in the vehicle with the 2-year-old. They were all taken to hospitals in critical condition.
A policeman across the freeway spotted the driver heading in the wrong direction just before the crash, but couldn’t reach them in time, police said.
Sunday’s crash was at least the second fatal misguided incident in the Houston area in the past month.
Three people were killed, including a toddler, in a July 9 fire crash on Westpark Tollway.
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