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A drug derived from ketamine, able to treat depression in a few days, should be available in the UK before the end of the year.
<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "Esketamine, one of the two molecules of & nbsp; 39 mirror image manufacturing up & nbsp;ketamine, is already available in the United States in intravenous form and was approved in March by the Food and Drug Administration (FDA) as a nasal spray. "data-reactid =" 23 "> esketamine, one of two mirror molecules ketamine, is already available in the United States in IV form and in March, the Food and Drug Administration (FDA) approved it as a nasal spray.
The drug will be reviewed by European and UK regulatory health agencies in November and next March. The National Institute for Excellence in Health and Care is expected to announce a decision regarding its use.
It will be available in private clinics at first, and a cost negotiation will have to take place before its deployment on the NHS, say the experts.
<p class = "canvas-atom canvas-text Mb (1.0em) Mb (0) – sm Mt (0.8em) – sm" type = "text" content = "Previous tests have shown patients whose & nbsp;depression& nbsp; has not responded to classic antidepressants, but some of them tend to improve quickly. "data-reactid =" 26 "> Previous tests have shown that patients depression did not respond to traditional antidepressants improve quickly, some in a few hours and days.
Traditional antidepressants usually take several weeks before patients undergo a change.
Professor Allan Young, a scientist at the Science Media Center, said there has been little change in the drugs used to treat depression in the last 50 to 60 years, adding, "People say we're still at the age steam and that go to the next technological advance and I think that's right. "
"What's exciting is the arrival of a new type of drug, ketamine.
"The novelty is that pharmacology is different, that it's not the same steam engine, that it works differently and faster."
"We know that classic antidepressants and, in fact, other treatments, put a long enough time to work, if you can actually improve things much faster, that's a good thing."
The business woman is depressed. She felt stressed and alone in the house.
Dr. Carlos Zarate, American co-inventor of a patent for the use of ketamine in the treatment of depression, said the side effects include reduced awareness of the immediate environment, brilliant dreams, communication difficulties and dissociation.
But because of the low doses used, compared to recreational uses, "people keep their vision, understand what's going on," he said.
He said previous test results were "outstanding" and said that scientists could take advantage of them "to develop better treatments that would not have the side effects or potential for abuse. ketamine ".
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Dr. Rupert McShane, who runs a ketamine treatment clinic at the NHS in Oxford, said "there is a lot of interest, it is intensifying".
But he added that access to esketamine could take some time as it would require a lot of time in the clinics.
Patients must spend two hours at the clinic as side effects decrease with the expected doses twice a week during the first month of treatment.
He is asking for an independent multi-drug registry where patients will log each ketamine or esketamine treatment via an app to track usage.
In my experience, it's a drug, not a miracle. But ketamine is, in my experience, and esketamine is, according to the data, a powerful and sometimes transformational anti-depressant. The risks seem low a year after trial esketamine populations, but the risk of adverse effects of long-term clinical use is simply unknown, and that is why a registration is really necessary. "
He added, "We must think about protecting the drug from inappropriate use."
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