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According to researchers, an ingredient commonly used in bread and baked goods to preserve foods could increase the risk of obesity and type 2 diabetes.
Propionate is often used to prevent mold in foods, but it has now been associated with an increase in hormone levels associated with weight gain and type 2 diabetes.
A team from the Harvard TH Chan School of Public Health, Brigham and Women's Hospital and the Sheba Medical Center in Israel began using mice to understand the effect of the disease. Ingredient on blood sugar.
They then applied their results to further study to determine if humans were affected in the same way. In total, 14 volunteers were divided. One group received a meal containing propionate and the other participants received the same meal, but with a placebo in place of the curator.
Blood samples were taken before and after each meal. The researchers found that propionate consumption triggered a series of metabolic events leading to insulin resistance and hyperinsulinemia.
Gökhan S. Hotamıslıgil, of Harvard Chan School, said, "Understanding how food ingredients affect the body's metabolism at the molecular and cellular level could help us develop simple but effective measures to combat the double epidemic of disease." Obesity and diabetes. "
The findings prompted researchers to question the safety of propionate, even though the US Food and Drug Administration approved it for public consumption.
Medical professor Amir Tirosh, who works at the Sackler School of Medicine in Tel Aviv, said: "The dramatic increase in the incidence of obesity and diabetes over the last 50 years years suggests the involvement of environmental and dietary factors.
"One of the factors that deserves our attention is the ingredients in common foods.We are exposed to hundreds of these chemicals daily, and most have not been tested in detail for their potential long-term metabolic effects. . "
The results were published in the journal Science Translational Medicine.
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