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LONDON, June 19 – A new large-scale British study has found that poor oral health may be linked to an increased risk of liver cancer, building on previous research that also had established a link between oral health and various diseases.
Conducted by researchers from Queen's University in Belfast, the new study looked at data on 475,766 people extracted from UK Biobank – a large, long-term study that included genomic data on more than 30,000 patients. half a million inhabitants of the United Kingdom, as well as data on brain imaging, their general information on health and medicine.
The researchers undertook to study the link between oral health and patient self-badessments for conditions such as painful or bleeding gums, mouth ulcers and loose teeth, as well as the risk of many gastrointestinal cancers, including the liver, colon, rectum and lung. pancreatic cancer.
The results, published in the United European Gastroenterology Journal, showed that although there does not appear to be a significant link between oral health and the risk of most gastrointestinal cancers included in the study, hepatobiliary cancer was strongly badociated ( liver).
The team also found that participants with poor oral health were more likely to be younger women, living in lower socioeconomic areas and consuming less than two servings of fruits and vegetables a day.
"Poor oral health has been badociated with the risk of several chronic diseases, such as heart disease, stroke and diabetes," said Dr. Haydee WT Jordão, lead author of the study. "However, there is conflicting evidence on the badociation between poor oral health and specific types of gastrointestinal cancers, which our research aimed to examine."
Although we still do not know how bad oral health can be badociated with liver cancer, rather than with other digestive tract cancers, one explanation is that the microbiome Oral and intestinal involvement may play a role in the development of the disease. "The liver contributes to the elimination of bacteria from the human body," says Dr. Jordão.
"When the liver is affected by diseases such as hepatitis, cirrhosis or cancer, its function will decline and the bacteria will survive longer and could therefore cause more damage. A bacterium, Fusobacterium nucleatum, originates in the oral cavity, but its role in liver cancer is unclear. Further studies on the microbiome and liver cancer are therefore warranted. "
The results are not the first time that oral health is badociated with a higher risk of cancer; An American study published in 2017 also found that women with a history of gum disease may be at higher risk of developing several types of cancer, particularly esophageal tumors and bads. – AFP-Relaxnews
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