How is the first human COVID trial that seeks to establish the minimum amount of virus needed to infect humans

The approach that directly involving people in disease screening is not new, it has played a role in the development of treatments for other diseases, from cholera to influenza. These trials speed up research on diseases and vaccines because volunteers do not need to be infected “naturally” in the community.

World’s First Human Coronavirus Testing Study Approved Today And To Begin In In a month’s time, the UK will attempt in its first part to establish the minimum amount of Covid virus needed to cause infection in healthy participants. It’s called a virus characterization study, and the protocol has now received ethical approval from that country’s health research authority, allowing it to move forward.

In addition, an attempt will be made to investigate the body’s immune response and explore how the virus is transmitted from person to person.

In this project, a maximum of 90 volunteers will be exposed to Covid, which will be chosen from participants between the ages of 18 and 30.. These individuals will receive compensation of 4,500 pounds (approximately $ 6,200) for their time spent studying. London Hospital will host the world’s first “human trials”. Participants will be closely monitored by doctors and scientists 24 hours a day after exposure to the virus. The team adds that the virus used will be the variant that circulated in the UK last year rather than those that emerged recently.

Firsthand

The trial is expected to give doctors a better understanding of Covid-19, as an immune response necessary to provide protection against disease, and help support the pandemic response by helping the development of vaccines and treatments. Those interested in participating have been invited to express their interest via the UK Covid Challenge website.

The study’s principal investigator, Dr Chris Chiu of Imperial College London, said they: “are asking volunteers between the ages of 18 and 30 to join this research effort and help us understand how the virus infects people and how it is transmitted so successfully among us. Our ultimate goal is to find out which vaccines and treatments work best to overcome this disease, but we need volunteers to support us in this work ”.

Trials will begin in a month’s time at the Royal Free Hospital in Hampstead, which has a unit specializing in infectious diseases. The maximum of 90 volunteers must show that they have no history or symptoms of Covid-19, have no underlying health issues and have no known adverse risk factors for Covid- 19, such as diabetes or overweight.

Volunteers will be quarantined for two days upon arrival at the Royal Free, where they will be allocated a private room with en-suite bathroom on the 11th floor “with great views over London”. They will then receive the smallest possible dose of covid and spend the next 14 days in the hospital, monitored and subjected to a series of tests.

They will be allowed to return home after a period of 17 days if they are no longer contagious and will be asked to participate in follow-up checks for the next 12 months as a condition of receiving the last installments of £ 4,500 in compensation.. Researchers say early payments resulted in £ 88 per day

Requests have not yet been submitted for other parts of the study, which could involve volunteers receiving a new test vaccine or a variant of the virus. It will use the “ original ” version of Covid that has been circulating in the UK since last March, which has been found to be low risk in healthy young adults, as opposed to the Kent or South African variants, which are all two faster in transmission.

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