They discovered a treatment that would kill all strains

May 7, 2021 13:10

Developed by two large North American companies, it works with monoclonal antibodies and has already shown encouraging results in the laboratory. Despite this, it is still under review.

Two large companies are advancing in the development of a treatment with monoclonal antibodies that could neutralize a significant number of strains of the coronavirus.

They are the pharmaceutical company Eli Lilly and the biotechnology company AbCellera Biologic. Together, they advanced into the lab with experiments like those for the antibody known as LY-CoV1404 or LY3853113. It adheres to a part of the virus which has shown little mutation in its different variants.

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In other words, this treatment could be successful whether it is Brazilian, South African and British strains or others. Therefore, it can remain effective over time.

The report, published on the website Biorxiv, states that “in pseudovirus studies, LY-CoV1404 retains potent neutralizing activity against many variants, including B.1.1.7, B.1.351, B.1.427 / B.1.429, P.1 and B .1,526 and binds to these variants in the presence of their underlying RBD mutations (which include K417N, L452R, E484K and N501Y) ”.

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He continues, “LY-CoV1404 also neutralizes authentic SARS-CoV-2 in two different tests against several isolates. The RBD positions which include the LY-CoV1404 epitope are highly conserved, with the exception of N439 and N501; in particular, the binding and neutralizing activity of LY-CoV1404 is not affected by the most common mutations at these positions (N439K and N501Y).

The specialists state: “New treatments resistant to variants such as LY-CoV1404 are desperately needed, as some of the existing therapeutic antibodies are less effective or ineffective against certain variants and the impact of the variants on the effectiveness of the vaccine is still unclear. not very well-known “.

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