Diario Salud – Brazilian scientists record a biomarker of non-alcoholic fatty liver disease

Studies Link this Disease to Polycystic Ovarian Syndrome

Researchers at the University of São Paulo Medical School (FMUSP), Brazil, recognize a biological marker of non-alcoholic fatty liver disease ( NAFLD). , a condition that affects people who accumulate fats in the liver even when they consume little or no alcohol.

The disease is strongly related to polycystic ovary syndrome, a hormonal imbalance that produces suspension of ovulation or ovulation. Irregular, this is what is called anovulation, which affects 15% of the female population of childbearing age.

Both conditions appear to be a consequence of insulin resistance.

The biomarker is discovered in rat tests and is currently being tested in humans. For results, 30 female rats with two days of life were divided into three groups and each was treated differently. The first group received 1.25 mg of testosterone hormone, the second 0.5 mg of estradinol and the third a placebo. The estradinol induction group reproduces a more benign syndrome phenotype

This study was conducted at the Laboratory of Structural and Molecular Gynecology (LIM-58) of the Chair of Gynecology of the FMUSP, following 39, a research project. that it has benefited from the support of the Support Foundation for Scientific Research of the State of São Paulo, as well as the coloring of the Federal University of São Paulo and the University from Michigan to the United States; and was the subject of Dr. Álvaro Anzai's mastery.

It is expected that the metabolic signature will be reproduced not only in the histological test but also in the blood test. Professor Gustavo Marcial, coordinator of the FMUSP group, explains that the preliminary studies carried out in collaboration with Professor Ismael Dale, from the Paulista School of Medicina of Unifesp, showed the increase of amino acids to branched chain in the blood of patients Insulin resistance

Marcial predicts that if the hypothesis that the biomarker behaves in the same way in humans is confirmed, it will be a big step in the diagnosis and the treatment of the disease. "What we are looking for is a noninvasive diagnostic method for non-alcoholic fatty liver disease for use in clinical practice," he said.

The team is also studying the effects of physical exercise on the general metabolic aspects of PCOS, and to verify whether there is a decrease in BCAA levels

Source: DYCT