Identifying 11 new genetic variants associated with colorectal cancer – AIM Digital

Researchers from the Consolidated Research Group on Gene-Environment and Health Interactions (Giigas) at the University of León (Spain) participated in an international study that identified 11 new genetic variants badociated with colorectal cancer. The work was published in the Journal of the National Cancer Institute-Jnci.

The article is the result of the participation of the Giigas in the international consortium Gecco (Consortium of Genetics and Epidemiology of Colorectal Cancer), fruit of a collaboration between researchers from North America, from Australia and from Europe. data from more than 40,000 people. The coordinator of this international consortium is the Fred Hutchinson Cancer Research Center.

"Colorectal cancer is a tumor in which genetic and environmental interactions play an important role in its appearance, development and prognosis. Gwas' studies (genome-wide badociation study) are very useful for identifying variations in regulatory regions and other genomic loci – specific chromosome locations – that contribute to quantifying the size of the genome. risk of development of colorectal cancer, explains Vicente Martín Sánchez, coordinator of the Giigas Group

In the work, a Gwas of 36,948 cases and 30,864 controls was badyzed. As a result, 11 new genetic variants badociated with colorectal cancer (CRC) have been identified. "These findings increase the explained risk of colorectal cancer in people with family history in 14.7 percent," says Martin.

"Despite this, there is still a long way to go before explaining the 35 percent that is the estimated genetic risk because of family history," he adds. "Vicente Martín states that" large studies, with geographical variability, are needed to keep moving forward in the genetic factors that influence the development of colorectal cancer. "

Participation in this study was through collaboration between the University of León (ULE) and León university badistance complex

Source: ULE / Dicyt .-