Studies suggest those who already had Covid should receive a single dose of the vaccine

The people who already had Covid-19, according to two new studies, they should be vaccinated in the same way against the virus. However, such research suggests that among them, a single dose of the vaccine would be sufficient to boost their antibodies and destroy the coronavirus – even the most infectious variants -, as published today in The New York Times. According to this note, the results of these new studies are consistent with what has been found by two other publications in recent weeks.

The article explains that the latest study – which has not yet been published in any scientific journal – analyzes blood samples from people who already had Covid-19 and the results suggest that their immune systems would have difficulty defending themselves against B .1.351, the variant of coronaviruses identified in South Africa. But point out that one dose of the Pfizer or Moderna vaccine boosted the amount of antibodies in his blood a thousand times. “A massive boost”, he said The New York Times Andrew T. McGuire, immunologist at the Fred Hutchinson Cancer Research Center in Seattle, who led the study.

Even the publication of the North American newspaper indicates that blood samples from all participants were able to neutralize not only B.1.351, but also the coronavirus that caused the epidemic of SARS in 2003.

“In reality, the antibodies seemed to work better than those of people who had not had Covid and had received two doses of a vaccine. Several studies have suggested that the Pfizer and Moderna vaccines are about five times less effective against the variant. [sudafricana]The note said.

He also explains that the researchers obtained samples from ten volunteers in the Covid study cohort in Seattle, who were vaccinated months after contracting the coronavirus. Seven of the participants received the Pfizer vaccine and three received the Moderna vaccine. According to the newspaper article, blood drawn two to three weeks after vaccination showed a significant increase in the amount of antibodies, compared to samples taken before vaccination. Researchers don’t know how long this antibody surge will last yet, but “let’s hope they last a long time,” McGuire said. The New York Times.

In another new study cited by the outlet, researchers at New York University found that a second dose of the vaccine did not bring much benefit to people who had had Covid-19, a phenomenon that has also been observed with vaccines against other viruses.

According to what the journal points out, in this study most people had been infected with the coronavirus eight or nine months before, but they saw their antibodies increase from one hundred to one thousand times during the first dose of the vaccine. After the second dose, the antibody levels did not increase further.

“It’s a real testament to the strength of immunological memory, that with just one dose they had a huge increase,” he said. The New York Times Dr. Mark J. Mulligan, director of the NYU Langone Immunization Center and lead author of the study.

“It is not clear whether the 1,000-fold increase in antibody levels recorded in the lab will occur in real life. Anyway, research shows that just one dose is enough to dramatically increase antibody levels ”, commented The New York Times Florian Krammer, immunologist at the Icahn School of Medicine at Mount Sinai in New York.

Dr Krammer – according to what is pointed out in the journal – led another of the new studies, which shows that People who had Covid-19 and received a dose of the vaccine had more side effects during inoculation and had more antibodies, compared to those who were not previously infected.

“If you put all four documents together, they provide very good information that people who have passed the infection only need a vaccine,” Krammer expressed to The New York Times.

For his part, Burton told them that these supercharged antibodies seen in the new study, which could fight the 2003 SARS virus, suggest that a single dose of the vaccine may have caused the volunteers to produce. “Highly neutralizing antibodies”, that is to say, molecules capable of attacking a wide range of viruses.

He also pointed out that, given the multiple variables of the coronavirus that appear to be more contagious or frustrate the immune system, the new study could provide clues about how to make a single vaccine that stimulates the production of this type of antibody capable of destroying all the variables of the coronavirus.

“In the long term, this is the way to fight this virus”, Burton told The New York Times. Without this vaccine – the note refers – scientists are going to have to adjust them each time the virus changes significantly.

THE NATION

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