Experimental compound inverse hair loss, inflammation of the skin related to a fat diet, studies on mice

In a series of experiments with mice, Johns Hopkins researchers used an experimental compound to successfully reverse hair loss, hair whitening and diaper-related inflammation in diets high in fat and cholesterol.

Researchers say the compound stops the production of certain fats called glycosphingolipids, or GSL, which are major components of the skin and other cell membranes. Current research shows that mice fed a diet high in fat and cholesterol are more likely to have discoloration of hair from black to gray to white, significant hair loss and inflammation of the skin exposed by multiple wounds. Feeding these animals, however, seems to reverse these symptoms.

Hopkins researchers warn that such results in mice do not mean that the same effects would occur in humans, and there is no evidence for the moment that the compounds used would be in security in people. But the results, they say, shed light on possible ways to treat hair loss and skin wounds in humans with oral or topical medications.

A report on the results was published on July 30 in Scientific Reports .

"Further research is needed, but our results are promising for a day using the drug we developed for skin diseases such as psoriasis and injuries resulting from diabetes or plastic surgery," explains Subroto Chatterjee, MS, MSc., Professor of Pediatrics and Medicine at the Johns Hopkins University School of Medicine. Chatterjee Conducts Research at the Johns Hopkins Children's Center

More specifically, previous studies have shown that GSL is widespread in the cells that make up the upper layer of skin, as well as in cells called keratinocytes

] Determine how disruptive GSL could affect the appearance and color of the skin, and whether treatment with D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) – – an artificial compound that interrupts the production of GSL – would negate any negative effect, Chatterjee and his colleagues first genetically modified a group of mice to have atherosclerosis, a disease in which the arteries are clogged by fat deposits.

fed a group of these mice a Western diet high in fat and cholesterol, and a second standard group chow. All mice were fed their badigned diet from 12 weeks to 20 weeks.

Compared with those fed standard food, mice that ate a Western diet lost their hair, formed skin lesions, and bleached their hair. These results became more severe when mice continued to eat a Western diet for 36 weeks, with 75 percent of mice having skin, hair loss and multiple skin lesions.

From 20 to 36 weeks of varying amounts of D-PDMP, either in a capsule or in liquid form, while they ate the same diet. Mice that received 1 milligram and 10 milligrams of D-PDMP in one capsule per kilogram of body weight from 20 to 36 weeks while eating a Western diet began to regain hair and hair color, and their skin inflammation was reduced. decreases. Treatment with 1 milligram of D-PDMP in one capsule per kilogram of body weight was as effective as 10 milligrams per kilogram of fluid. This suggests that an encapsulated form of D-PDMP is a better method of drug delivery.

The research team then examined the skin of the mice under a microscope and found that mice eating the western diet experienced an infiltration of neutrophils, a type of white blood cell involved in inflammation, in various areas of the skin. Treatment with D-PDMP in a capsule significantly reduces the number of neutrophils, which implies reduced skin inflammation and injury.

Next, the researchers used mbad spectrometry badysis, a method to identify and quantify the chemical composition of a mixture. , glucosylceramide and lactosylceramide in mice. Ceramides are a type of lipid, or lipid, that helps protect the skin's hydration, and glucosylceramide is the first derivative of ceramide, while lactosylceramide, a later derivative of ceramide, activates the skin. Inflammation

. a western diet had decreased total ceramide levels, reduced glucosylceramide and almost three times more lactosylceramide. Treatment with 1 milligram of D-PDMP in one capsule per kilogram of body weight or 10 milligrams of D-PDMP as a liquid per kilogram of body weight, however, significantly increased ceramide levels to normal.

"Our results show that a Western diet causes hair loss, hair whitening and inflammation of the skin in mice, and we believe that a similar process is occurring. produced in men who lose their hair and whiten their hair when they eat a diet high in fat and cholesterol. "1965b Research is needed to confirm and deepen discoveries, and to determine how much and how much D- PDMP could heal wounds and activate hair growth.

"Hopefully, someday, it could mean faster and more effective healing. baldness, hair bleaching in aging populations and wound healing, "says Chatterjee