Heart failure: a new stem cell therapy can restore heart function up to 90% after a failure

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NEW YORK: Stem cells can potentially be used as a "unique" approach to restore function in people with heart failure, revealed a study.

Reported in the journal Nature Biotechnology, the study showed that treatment of human stem cells can eventually reduce heart function to more than 90% of normal in macaques with heart attacks.

Heart failure that causes nearly 10 million deaths worldwide is a disease caused by a lack of blood circulation. Stem cells will help "train new muscles that will integrate into the heart so that it can pump vigorously again," said Charles "Chuck" Murry, a professor at the University of Washington .

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MRIs showed that the new heart muscle had grown up in what had been scar tissue in the treated hearts, whereas no new muscle was observed in untreated animals.

In addition, human heart cells also formed new muscle tissue in the damaged region. The new muscle tissue had replaced 10 to 29 percent of the scar tissue, integrated with the surrounding healthy tissue and developed into mature heart cells, the researchers said.

Murry said the research aims to develop a treatment that could be given to people shortly after a heart attack to prevent heart failure.

Because heart cells have a long life span, there should be no need for additional treatments, he said. The transplanted stem cells would also be genetically engineered to reduce the risk of immune rejection, which often complicates organ transplantation.

"What we hope to do is to create a" one-of-a-kind "treatment with frozen" ready-to-use "cells that, like O-negative blood, can be administered to any recipient. with moderate immunodepression "Murry said.