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Innovative nanoparticles filled with drugs, successfully triggered in the body by X-rays, have been developed by researchers, paving the way for a new range of cancer treatments for patients .
like liposomes, are commonly used in pharmacology to encapsulate drugs, making them more effective in treating the disease. Researchers have now successfully designed these liposomes to unload their cargo of prescription drugs, once activated by standard X-rays. Early tests have shown that this technique is very effective at killing intestinal cancer cells.
"The development and application of various models of nanomaterials for drug delivery is currently a key area of nanomedicine," Dr. Wei says. Deng, a research badociate at the ARC Center of Excellence for Nanoscale Biophotonics (CNBP) and a researcher at Macquarie University when the research was undertaken. "Liposomes are already well established as an extremely effective drug delivery system." Made from materials similar to cell membranes, these "bubbles" are relatively simple to prepare, can be filled with appropriate drugs, The question is, however, to control the rapid release of the drug by the liposome. "
" We have ensured that liposomes release their drug load at the right time and in exactly the right place for Ensure the most effective treatment One way to do this is to trigger the liposome collapse when and where it is needed.Our X-ray trigger liposomes allow this drugrelease on demand to occur, "says Deng . "The approach we adopted was to incorporate gold nanoparticles and the photo-sensitive molecule ve rteporfin in liposome wall. "
" X-ray radiation reacts verteporfin and produce highly reactive singlet oxygen destabilizes the liposomal membrane, causing release of the drug, "Deng explains. "The gold nanoparticles are added to the mix by focusing the energy of X-rays. This enhances the generation of singlet oxygen and therefore improves the rate of membrane rupture," she says.
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