[ad_1]
July 11, 2018
A team of researchers from Queen Mary University of London reported the genetic events involved in the early development of bowel cancer in patients with anemia. inflammatory bowel disease (IBD).
can be exploited to design simple diagnostic tests to stratify IBD patients at high risk of developing cancer.
IBD more than doubles the risk of developing bowel cancer, and greatly increases the risk of IBD. extended period. With this in mind, the study published in Gut carried out in collaboration with researchers from St. Mark's Hospital and the University of Oxford, aimed to understand the genetic development of colorectal cancer in people with IBD
. Professor Trevor Graham, a researcher at the Barts Cancer Institute of Queen Mary, said, "Predict who will suffer from IBD will develop bowel cancer is a great unmet need, if we could do it with accuracy, this would allow us to target those who Here we determined which genetic mutations tend to occur early in the development of colon cancer badociated with IBD These mutations could form the basis of a simple diagnostic test for predict who is at high risk. . "
Establishment of a Sequence of Genetic Events
The team examined the genetic sequences of samples of cancerous and non-cancerous tissues collected from IBD patients with colorectal cancer By comparing the sequences, researchers were able to establish a chronology of events leading to the development of malignancy.
Notably, the badysis identified some genetic alterations that tended to occur. produce early in progression to cancer, like the tumor suppressor protein known as p53.P53 changes that cause impairment or loss of function usually occur later in the development of cancers of the body. Gut that are not badociated with IBD, highlighting some genetic differences between colorectal cancer cases developed by IBD and those that do not. The changes in the number of copies of certain chromosomes – the structures that carry our genetic information in the form of genes – were also common in the vast majority of IBD colon cancer samples accumulated at the beginning of their calendar. evolutionary
. The team hopes that spotting these early genetic changes could serve as indicators for identifying IBD patients who are at immediate risk of bowel cancer, which will require close monitoring of the patient and will allow fast interception of the best treatment options. On the other hand, people with IBD who are not at risk of developing cancer could be spared unnecessary worries.
Future Guidelines
The first author, Dr. Annie Baker of the Queen Mary Barts Cancer Institute, said: Exciting research, we investigated how colon cancer badociated with IBD develops over time, identifying the crucial genetic changes that occur before or at the beginning of the malignancy. Our results have provided a solid foundation for future work, which will focus on how we can use "
The team recently received funding from Cancer Research UK (CRUK) as part of the Early Detection funding stream to validate the fact that these genetic indicators are indeed effective markers of research. cancer risk. This is in addition to ongoing efforts, funded by Barts Charity, to identify prognostic biomarkers of bowel cancer in other groups of patients with IBD.
[ad_2]
Source link
