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For the first time, antibodies were detected in a kidney transplant.
12:13, July 17, 2018
According to Viennese scientists ( MedUni / AKH), in addition to IgG antibodies – as has been known for decades – also other antibodies that are normally badociated with allergies, contribute to the rejection reaction after transplantation. organ. The experts had first detected IgE antibodies after kidney transplantation, reports the MedUni
(Transplantation Report 2017: 780 patients in waiting list)
(birthday gift: mother gives kidney daughter)
Up to now, rejection reaction after organ transplantation has been attributed mainly to antibodies from the donor organ G-type directed immunoglobulins (IgG). In contrast, IgE antibodies are "normally" known for their important role in the development of allergies. For example, E immunoglobulins are directed against really harmless antigens such as pollen, which can trigger an allergic reaction.
"Transplantation is another type of IgE antibody that targets the tissue characteristics of the donor kidney" author of the study Andreas Farkas was quoted in a press release. "IgE is responsible for local inflammation and, as our current hypothesis suggests, could be involved in the eventual rejection of the organ with IgG antibodies."
The work was done by experts from the Department of Surgery of the University. Researches on pathophysiology and allergies and the clinical service of nephrology. "This new idea could also lead to all-new diagnostic options," said transplant immunologist Thomas Wekerle. The IgE test can help better badess the risk of subsequent rejection. There are also ways to add IgE via special filter columns from the bloodstream
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