Antibodies to Renal Disease

Augusta (pte009 / 30.07.2018 / 11: 30) –

The use of an artificial version of a human antibody to administer a drug directly, according to a study by researchers at the Medical College of Georgia http://augusta.edu/mcg, can reverse the course of the disease, which often leads to kidney failure and dialysis.

Revitalizing mitochondria

The researchers also found that mitochondria function, particularly affected by nephritis, or acute or chronic inflammation, can be restored, at least in animal models and cell cultures. An infection or serious injury and conditions such as uncontrolled high blood pressure and diabetes can result in acute or chronic nephritis affecting both kidneys.

The study used a model of immune-mediated nephritis in mice – a disease that has spread in the kidneys. developed from seven to ten days and progressing rapidly. A few days after the disease, the animals received a single dose of the protein kinase C-alpha inhibitor directly into the kidneys via the artificially produced antibody. In these animals, renal function recurred and they survived. Parallel studies have allowed researchers to study the effects of toxicity and treatment on endothelial cells in the areas responsible for filtration. Cell death was reduced and cell repair was improved

Blockade of Inflammation

Proteomic badysis identified 157 proteins that were significantly altered in nephritis. These values ​​could be further improved by the treatment. Among the changes, especially the mitochondria have been particularly affected. All studies have demonstrated the crucial role of protein kinase C-alpha in nephritis damage. In addition, according to principal investigator Michael P. Madaio, initial evidence has been provided that blockage may be effective in the treatment of this inflammatory disease

In the treatment of nephritis, high doses of inflammation and systemic immunosuppressive drugs such as used after a transplant. Side effects include increased risk of infection or even cancer. Madaio therefore hopes that a targeted approach, such as the one being developed, could be more effective with fewer side effects. The results of the research were published in "Kidney International".

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