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Researchers at the University of Graz have come to the root of a reason why inflammatory reactions in obese people may be more pronounced. The transformation of brown adipose tissue into white tissue plays a role here.
More specifically, the brown fat cells, in which fat is burned, become white fat cells that store energy in the form of fat drops. This transformation results in inflammatory reactions, as Graz scientists are now observing at the Institute of Molecular Biosciences
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Obesity accompanied by Reactions inflammatory in the adipose tissue, which promote the development of diabetes or cardiovascular diseases
19659006] The molecular biologist of Graz Petra Kotzbeck explains the "discoloration" of adipose tissue as follows: "The brown fat cells, which actually have a lot of small droplets of lipids, are similar in appearance to white fat cells and increase in size. " Researchers have observed that conversion from brown to white on the fat cells of laboratory mice is accompanied by an inflammatory reaction that, according to Kotzbeck, is much more pronounced than in conventional white adipose tissue. The research "publishes:" P. Kotzbeck, G. Haem Merle, R. Zechner, MP Cecchini, EE Kershaw: "Bleaching brown adipose tissue leads to death of brown adipocytes and inflammation of adipose tissue" , Journal of Lipid Research, Vol. 59/2018
World Research
Fundamentally, white adipose tissue also changes in very overweight individuals. out, is dysfunctional and develops a mildly inflammatory condition. However, such inflammations can also promote the development of diabetes or cardiovascular disease.
Worldwide, people are studying the causes of obesity obesity in order to develop effective therapies. The latest findings from Graz researchers have been published in the Journal of Lipid Research.
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