Scientists have claimed that the treatment of age-related hair loss could be ongoing, according to a new medical breakthrough.
The researchers believe they have discovered how to gradually reverse the bald process by successfully pushing the hair on the injured skin.
Scientists at the New York School of Medicine have activated a pathway in the brain called the sonic hedgehog.
This pathway is very active when babies are in the womb and hair follicles form, but is blocked in old or injured skin.
Researchers believe they have discovered how to progressively reverse the bald process by successfully repelling hair on injured skin
The figures suggest that about 25% of men start to become bald at the age of 25 and that Prince William begins to lose weight at just 22 years old.
According to the American Academy of Dermatology, women can also suffer from visible hair loss in 40% of them.
The study examined damaged skin in laboratory mice, focusing on cells called fibroblasts that secrete collagen.
Collagen is an essential protein for maintaining the shape and strength of skin and hair.
Researchers have also been interested in fibroblasts because cells are known to help direct some of the biological processes involved in healing.
The team, led by Dr. Mayumi Ito, has activated the sonic signaling pathway of the hedgehog, which is used by cells to communicate with each other.
By stimulating communication between these cells, hair regrowth was observed within four weeks in the mouse.
According to an essay published in Nature Communications, hair roots and stem structure began to appear after nine weeks.
Scientists have hitherto assumed that scarring and accumulation of collagen in damaged skin was at the root of its inability to regrow hair. But this proof brings a new light.
What are the causes of hair loss?
Hair loss is common: about 25% of men start to become bald at age 25, according to the American Hair Loss Association.
In the United Kingdom, an estimated eight million women suffer from hair loss, according to a study of 2,000 women conducted by cosmetics giant L'Oreal.
The most common type of hair loss can be caused by events such as moving, grieving or pregnancy, resulting in general thinning of the hair.
Hair loss is also associated with yo-yo dieting, birth control pills, stress, eating disorders, chemicals in water, and modern pesticides in foods.
In most cases, hair loss is temporary and can be helped.
Nutritionists might say that if nutrient levels are low, they will be expressed by the hair. Hair follicles rooted in the scalp must be surrounded by a rich supply of blood to ensure adequate nutrition.
Dermatologists suggest that fad diets usually lead to iron deficiency, as does the avoidance of red meat. Vegetarians or vegans who are low in vitamin B12 and zinc may be prone to losing hair.
Research shows that sparse hair is also linked to progestins – the synthetic form of progesterone found in the substitution treatment of pills and hormones.
Dr. Ito said: "We now know that it is a signaling problem in very active cells as we grow in the uterus, but less in mature skin cells with the disease." 39; age.
"Our results show that stimulating fibroblasts by sonic hedgehog can trigger hair growth never observed in wound healing."
Regrowing hair on damaged skin is an unmet need in medicine, said Dr. Ito, due to the disfigurement of thousands of people with trauma, burns and other injuries.
It's not only a breakthrough for injured skin, but the evidence is promising for improving hair growth in mature skin, she added.
This can help in the search for better medicines to restore hair growth.
Other experiments on the way of the sonic hedgehog have revealed a higher risk of tumors.
To avoid these risks, the team activated only the fibroblasts located just under the surface of the skin, where the hair follicle roots (dermal papillae) appear.
With positive results, Dr. Ito said it suggests that this barrier may have been overcome, bringing science closer to true skin renewal after an injury.
The goal of the doctor is to identify the likely therapeutic targets for hair regrowth. Currently, licensed drugs can have undesirable side effects.
Minoxidil, an over-the-counter foam or lotion, works by increasing blood flow to the scalp and nourishing the hair follicles.
It helps about two-thirds of patients, men and women – but can have side effects ranging from rapid heartbeat to swelling of the feet and abdominal pain.
Finasteride, is available only on private prescription for men. It works by blocking an enzyme that converts testosterone into dihydrotestosterone (DHT), another form of hormone that triggers baldness.
Research shows that finasteride triggers hair growth in 80% of men, but one in 60 suffers from impotence – and the risks increase with the duration of your treatment