NEW YORK: Scientists, including an Indian descent, have found a way to reverse the action of wrinkled skin and hair loss that are considered aging features , in a mouse model.
The results showed that when a mutation leading to mitochondrial dysfunction is induced, the mouse develops wrinkled skin and significant and visible hair loss within a few weeks.
However, when mitochondrial function is restored by extinguishing the gene responsible for its dysfunction, the mouse returns to the smooth skin and thick fur, indistinguishable from a healthy mouse of the same age.
According to the study's authors, the decline in mitochondrial function in humans is visible during aging, and can lead to age-related diseases.
They found that, the mice showed gray hair, reduced hair density, hair loss, slowed movements and lethargy in four weeks. Wrinkled skin was observed four to eight weeks after induction of the mutation, and females had more severe skin wrinkles than males.
Inversion of the mutation restores mitochondrial function, as well as cutaneous and capillary pathology.
However, little change was observed in other organs when the mutation was induced, suggesting an important role for mitochondria in the skin compared to other tissues.
"This suggests that the epigenetic mechanisms underlying mitochondrial nucleus crosstalk must play an important role in restoring the normal skin and hair phenotype," said Singh.
The Ultimate Health Guide: 6 Foods to Keep Cholesterol …
The Call of Cholesterol
March 20, 2018
By Ayush Rekha
The first step to having healthy cholesterol levels is examining your diet.
Here are some foods that can help keep your lipid profile in the desired range.
Almonds
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High in unsaturated fatty acids, almonds help raise healthy cholesterol and reduce bad eating habits (LDL)
Tea
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Green tea and black tea can help lower cholesterol levels.
Onion Family
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Garlic, onions and other onions can be used to lower cholesterol and protect the heart.
Tomatoes
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An important source of lycopene, tomatoes are known to reduce LDL cholesterol levels.