[ad_1]
According to a new study carried out at the University of São Paulo (USP) and at the Faculdade de Ciências, the physical, social and leisure activities of elderly people and patients suffering from the disease. Alzheimer's can help preserve cognitive functions and delay memory loss. Doctors of Santa Casa de São Paulo. Stimuli promote morphological and functional changes in the brain, which protect the organ from damage resulting in cognitive loss.
The discovery was made by means of an experiment on transgenic mice, genetically engineered to have super plate expression. in the brain. These plaques are one of the hallmarks of Alzheimer's disease. The animals were separated into three groups: transgenics that would receive stimuli, transgenics that would not receive, and control animals not affected by the disease. [196459002] Read also: The Possible and Surprising Cause of Alzheimer's Disease
"When they were a little older, around 8 to 10 months old, we put some of these animals in an enriched environment , a box with several toys, and we changed them every two days, "said Tania. Viel, professor at the USP Faculty of Arts, Humanities and Social Sciences and coordinator of the project
The experiment lasted four months, following which they were submitted to the USP. evaluation of motor activity, using sensors and spatial memory. , with a test called Barnes' Labyrinth. The results show that toy-stimulated transgenic mice had a 24.5% reduction in the time required to comply with the labyrinth test, compared to animals that were not in the enriched environment.
Read more: Brazilians report that the stress hormone can stop Alzheimer's disease
The mouse brain was also badyzed. When verifying brain tissue samples, the researchers found that the transgenic animals that pbaded through the stimuli exhibited a 69.2% reduction in the total density of senile plaques compared to those that were not stimulated.
. senile plaques, they have increased a protein that helps clean this plaque. It is the SR-B1 receptor, which is expressed in the microglia cell. The receiver ensures that this cell attaches to the plates and helps to remove them. "The control animals, without the disease, had this protein that helps clean the plaque, even everyone produces it." Alzheimer's animals had a very strong reduction in this protein and animals in the enriched environment [que tiveram estímulos] were similar to control animals, "explained Viel.
See also: Alzheimer's disease: Patients asking for euthanasia to die before the disease dominates them
The researcher claims that his work are proof of earlier hypotheses and that the group is now working to extend verification in dogs and humans by first searching for markers in the blood indicating the relationship with Alzheimer's disease. [19659002] "In rats, we badyze the brain and blood to see if these biomarkers are in both the brain and the blood. When the person loses memory, there are proteins that increase in the brain and others that decrease. In dogs and in humans, we only see blood, "he said.With the discovery of these markers in the blood, it will be possible to perform experiments similar to mice with motor tests and of memory to confirm or exclude changes in dogs and humans after stimuli.
with Alzheimer's disease, one can surgically cure
For Tânia Viel, as one does not do not know which human will develop the disease, the more the stimulation of his life will increase, the better will be the protection of the brain. "This changes your routine. Many people say they do not have time to do anything else, but if the person has conditions and can walk in the block, it starts with a physical and playful activity, walking with a dog, with a child, a language course, dance.
The study was published in the journal Frontiers in Aging Neuroscience and received support from the Foundation for Research Support of the State of São Paulo
Appropriate Care contribute to the patient's life. caregiver and the person with Alzheimer's:
Source link
