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The administration of low-dose aspirin – a drug commonly used to treat pain, fever or inflammation – may help reduce plaques in the brain, reduce the pathology of the Alzheimer's disease and memory protect, reveals a study conducted by a researcher of Indian origin
The results showed that the over-the-counter drug decreases amyloid plaque – the main signs of the disease of Alzheimer's pathology in mice by stimulating lysosomes – the component of animal cells that help clear cellular debris. identifies a possible new role for one of the most prevalent and prevalent over-the-counter medications in the world, "said lead author and senior researcher, Kalipada Pahan, of the Rush Department of Neurological Sciences Medical College
. The research adds another potential benefit to the already established uses of aspirin for the relief of pain and for the treatment of cardiovascular disease, "said Pahan.
In the study, p published in Journal of Neuroscience, the team administered aspirin orally for one month to genetically modified mice with Alzheimer's disease, then badessed the amount of amyloid plaque in the brain parts of the brain. Most affected by Alzheimer's disease
the drugs increased TFEB – a protein considered to be the main regulator of waste elimination, stimulated lysosomes, and decreased amyloid plaque pathology in patients with mice. Read: Can taking daily aspirin affect my health? Our expert responses
"Understanding how plates are removed is important for d develop effective drugs which stop the progression of & # 39; Alzheimer's, "said Pahan.
However, experts have questioned the potential of aspirin. human trials in drugs that reduce amyloid plaques.
"A number of compounds reached this level of amyloid reduction in mice, but subsequently failed in clinical trials in humans," Clive Ballard, of the University of Toronto. Exeter by saying to newatlas.com. Read: There is a link between obesity, aspirin and cancer risk
"Failures can result from differences between Alzheimer mice and human pathology, and from the poor translation of benefits in humans "Furthermore, in human clinical trials, the drug had" no beneficial effect on outcome measures and was badociated with an increased risk of gastrointestinal bleeding. " intestinal, "notes Rob Howard, of University College London
. ] Source: IANS
Source of the picture: Shutterstock
Posted: July 4, 2018 9:34 AM
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