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New research shows that the use of anticonvulsants for the treatment of low back pain or lumbar radicular pain is ineffective. The study, published in Journal of the Canadian Medical Association also showed that the use of gabapentinoids had an increased risk of adverse events.
Oliver Enke
"Between 2013 and 2014 More than 1.3 million prescriptions were written for anticonvulsant pregabalin in Australia, and the prescription of anticonvulsants in care primary has increased by 535% over the past 10 years. " Oliver Enke MBBS, MD, MSc, from the University of Sydney, stated Healio Family Medicine . "We also conducted our own trial of pregabalin anticonvulsant in patients with sciatica, which showed that pregabalin was not effective.This systematic review was intended to gather evidence beyond our trial and to see what the summary of data says. "
Enke and colleagues conducted a systematic review of nine randomized placebo-controlled trials of the effects of anticonvulsants on low back pain.The trials included 859 unique patients and compared topiramate, gabapentin or pregabalin to placebo
According to the study, the average age of participants in the treatment group was 50.8 years whereas the placebo group had an average of Age 51.5 years Patients with chronic low back pain with or without radicular pain in the legs were enrolled in four trials, and patients with lumbar radicular pain on were recruited in five trials. Numerical scales of self-badessment of pain have been used in most studies, and only one has used a pain index based on descriptors. The researchers added that most studies only mentioned immediate or short-term data.
Enke stated that their review determined that there is moderate to high quality evidence that anticonvulsants are ineffective for these conditions. According to him, gabapentinoids have a higher risk of adverse effects such as drowsiness, dizziness, nausea. "The message to remember is that anticonvulsants are not effective and can cause side effects in people." Enke says:
He said that physiotherapy is something that should be considered early so that patients stay active and
"Consensual recommendations for the treatment of nonspecific low back pain focus on a thorough patient education and counseling to stay active," said Enke. 39, improve with time and the patient can be rebadured. "- by Jake Scott
Disclosure
s
:
Enke does not report any relevant financial disclosure. Please see the full study for the relevant financial disclosures of all authors.
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