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A team of researchers from University Medical Center (UMC) Utrecht in the Netherlands experiment with 3D bioprinted tissues that can be implanted into a living joint affected by arthritis [19659005]. The method should allow the replacement of damaged cartilage .
Arthritis is a common disease affecting approximately 350 million people worldwide. With more than 100 types of arthritis, this disease involves the disintegration of cartilage tissue in the joints, leading to pain, stiffness, and inflammation.
Using 3D bioprinting, patients can receive specific and on-demand cartilage as original cartilage to strengthen joints and reduce joint pain.
"Printing is not the last stage of biofabrication because printing something heart-shaped does not actually make a heart," said Jos Malda, professor of biofabrication in translational regenerative medicine at UMC Utrecht.
"Printed construction needs time and the correct chemical and biophysical indices to mature in a functional fabric."
Bioinks and Experimentation
As part of [19659002] Project 3D JOINT funded by the Horizon Vision 2020 of the EU [19659002] to encourage innovation in research on the continent, Professor Malda and his team rely on the capabilities of 3D printers and stem cell deposition.
Using the 3D bioprinting technique and following a precise medical plan, stem cells are deposited by 3D printers creating layer-by-layer complex tissues.
As demonstrated by Bioprinted Human Biota of the University of Newcastle Bioink Solutions Created from Stem Cells and Hydrogels of Donor ] – a clbad of materials made up of large molecules such as polymers – can produce living conditions for the organisms of the human body
. the challenge of maintaining the right conditions for a cellular building material, Professor Malda integrated hydrogel into the cartilaginous tissue.
"For bioprinting, the material must be able to keep the cells alive, which requires aqueous conditions and relatively low temperature processing, making hydrogel-based materials the ideal candidates. "
However, the softness of these hydrogels is at a disadvantage, according to Professor Malda. This is due to his inability to resist the mechanical forces that certain tissues undergo in the body.
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