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Unlike humans, rats can not vomit.
But that did not stop researchers from using rodents in a study that laid the foundation for understanding how a component of cannabis that does not reach the high level could eliminate nausea .
According to an article published Tuesday by researchers at the University of Guelph and the University of Calgary, the non-psychoactive component contained in the pot, cannabidiol (CBD) can suppress the triggering factor of the nausea
. Doctors already prescribe tetrahydrocannabinol (THC) capsules – the psychoactive component in cannabis that gives users a euphoric feeling – to treat chemotherapy-induced vomiting and nausea, but this is the first time that CBD has the potential to treat symptoms. "The next step would be for someone who undertakes clinical research on humans to learn about this research," said Linda Parker, Canada Research Chair in Behavioral Neuroscience at L & # 's. 39, a study, published in the scientific journal eNeuro, showed that a nausea-inducing treatment in rats releases serotonin in the interocephalic insular cortex – the region of the brain badociated with vomiting in the rat and l? man – but an injection of CBD prevents the release.
"We had previous work that led to the hypothesis that it's what it's going to do, but we have not had a direct measure of it. "said Parker, author of a book on" Indeed, what we found was that the peak serotonin was prevented by pre-treatment with cannabidiol. "
The team also prevented the release of serotonin in rats using a drug that increases levels of 2-4. AG, a cannabinoid naturally produced by the brain to reduce the symptoms of nausea.
Rats can not vomit, but they have a gaping response that researchers measure to reflect nausea,
Canada will become the first G7 leg alize recreation marijuana – Uruguay is the only country another country to do it – on October 17th.
Although cannabis has been prescribed for medical purposes for almost two decades, little research has been done on its short- and long-term effects. Scientists have also not fully explored the therapeutic potential of the more than 100 cannabinoids that make up the plant.
"We know so little about how it works," said Parker. "We are far behind, it will take many years, decades, to know which combination of cannabinoids will produce what effect."
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