Withdrawal from the schedule could reduce the risk of Parkinson's disease

A new study found that early removal of the appendix could reduce the risk of Parkinson's disease by 19-25%.

Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease, according to US Centers for Disease Control and Prevention.

The first symptoms of the disease include rigidity and tremors. As you progress, people may have difficulty walking and talking. They may also have problems with sleep, depression, fatigue, memory problems, and mental and behavioral changes.

The most common non-motor symptoms of the disorder include gastrointestinal tract problems, suggesting that Parkinson's disease can develop in the gut.

First, the appendage attached to the lower part of the large intestine and open to it contains the protein called alpha-synuclein, which is known to accumulate or clump in the brains of people with the disease. Parkinson's.

The researchers said that this protein did not like to stay in place. Viviane Labrie, of the Van Andel Research Institute in Michigan, said CNN that the protein can move from neuron to neuron and that it is able to travel.

This means that alpha-synuclein can move up the vagus nerve that connects the gastrointestinal tract and the brain.

"If it were to enter the brain, it would then germinate and spread and have neurotoxic effects that could eventually lead to Parkinson's disease," Labrie said.

To link the appendix to Parkinson's disease, Labrie and her colleagues looked at the medical records of 1.6 million adults and found that those who had an appendectomy had a 19.3% chance of developing the disease. Parkinson disease.

A second badysis of 849 patients with Parkinson's disease also revealed that an appendectomy was related to a delay in the onset of the disease by 3.6 years on average.

However, appendectomy does not appear to have any effect on the development of Parkinson's disease in people with a family history or a genetic risk of the disease.

The results of the study, published in Translational medicine science, strengthen the role of the gut and the immune system in the development of the disease and show that the appendix serves as a major reservoir for abnormally folded alpha-synuclein proteins, closely badociated with the onset and progression of Parkinson.

"We determined the ability of the appendix to alter the risk of PD and influence pathogenesis," the researchers wrote in their study. "We propose that the normal human appendix contains pathogenic forms of α-synuclein that affect the risk of developing an MP."