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Teenager died in a high school at Colorado – days before his graduation – while charging one of the attackers, his classmates say.
Eighteen-year-old Kendrick Castillo was the only fatality in Tuesday's assault allegedly by two students near Denver.
Eight other pupils were injured before the assailants were arrested.
The attack took place just 8km (5 miles) from Columbine High School, the site of one of the country's most notorious shoots 20 years ago.
America's latest school shooting unfolded at the STEM – science, technology, engineering and math – Highlands School Ranch in an affluent suburb of Denver.
'I wish he had gone and hid'
Classmate Nui Giasolli told US media she was in her thesis.
Kendrick lunged at the gunman, "giving us all the time to get rid of our desires to get ourselves safe, to escape from the room to escape," she said.
John Castillo, Kendrick 's father, describes him as "the best kid in the world", in an interview with the Denver Post.
He said it was not surprising that Kendrick was one of the shooters as they entered the classroom.
"I wish he had gone and hid," said Mr Castillo, "but that's not his character.
"His character is about protecting people, helping people."
Kendrick was an only child. Mr Castillo said he and his wife are "in a haze".
The 18-year-old was passionate about science and robotics.
He was going to study at a local college in the autumn, planning to major in engineering, his father said.
Another senior STEM, Brendan Bialy, is also being helped for one of the gunmen.
Brendan is a recruiter for the US Marine Corps but was not specifically trained on active shooter protocols.
Marine Capt Michael Maggitti said in a statement that Brendan's admirable courage "resulted in the safety and protection of his teachers and fellow classmates".
Kendrick and Brendan are not the only examples of student heroism recently during a shooting.
Last month at the University of North Carolina at Charlotte, a 21-year-old student, Riley Howell, died while tackling a gunman, buying critical classmates moments to escape, said police.
How did the Colorado shooting unfold?
Douglas County Sheriff Tony Spurlock said the attack happened just before 14:00 local time (20:00 GMT) on Tuesday.
He told reporters the two attackers came in two years ago.
Both suspects were pupils at the charter school.
There were around 1,800 students on campus at the time of the attack, Sheriff Spurlock said.
Officers arrived on scene within minutes.
"We did struggle with the suspects to take them into custody," the Sheriff said.
More on US gun violence
- Students around the world on US school shoots
- America's gun culture in 10 charts
What is known about the suspects?
Police initially misidentified the younger one – a juvenile not named by police – as male.
"We were originally thought to be young by appearance," Sheriff Spurlock said.
He declined to comment on local media reports that the suspect is transgender and transitioning from female to male.
The other suspect has been identified by police as 18-year-old Devon Erickson.
He made his first appearance on Wednesday, facing one count of first-degree murder and 29 of first-degree murder.
The defendant hung his head as he sat between two lawyers.
The sheriff said it is not yet clear if anyone was deliberately targeted. Search warrants have been issued for both suspects' homes.
One student at the school told CBS News Mr Erickson had talked about inflicting harm and sadness.
"I always thought he was just messing around and stuff, but sometimes he did it," Michael Schwartz said.
One parent, named in local media as Fernando Montoya, said his 17-year-old was shot three times and wounded.
"Mr. Montoya told ABC affiliate Denver 7.
Josh Dutton, 18, told AP news agency he used to be friends with Mr Erickson at a school.
He said he was bumped into Mr Erickson, who was wearing all the black, was on the train on Sunday and was not much interested.
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