Neuroscientists removed the plaques responsible for Alzheimer's from the brain of mice using only light and sound. Is it really possible? We explain
Research conducted by MIT has revealed that strobe lights and a severe hum can recreate the brainwaves lost in the disease, then eliminate clumps of harmful proteins that accumulate around the brain of mice with behaviors similar to those of Alzheimer's disease.
The non-invasive procedure improved cognitive function and memory of the mouse. After a week of treatment, mice were much better able to navigate a labyrinth by remembering landmarks.
Mice and human brainwaves work differently, and the process has not yet been tested in humans, but the discovery is promising as it could provide a way to treat Alzheimer's disease inexpensively and cheaply. without medication.
The research is based on a previous study in which mice with Alzheimer's disease were treated by projecting a light 40 times per second into their eyes, which treated their disease. In this study, the sound was added and the results were significantly improved.
"When we combine stimulating visual and auditory stimulation for a week, we find commitment to the prefrontal cortex and a very dramatic reduction in amyloid," the main author Li-Huei Tsai said.
Alzheimer's disease disrupts the processing and communication of information by neurons in the brain and causes loss of function and cell death. In the Alzheimer's brain, high levels of protein agglutinate to form plaques that disrupt the functioning of neurons.
Previous studies have examined the role that sound can play in eliminating brain tau and amyloid proteins that contribute to the disease. The microglia of the nervous system, which cleans the waste, is stimulated by the treatment.
When mice listened to one hour of buzz a day for a week, amyloid accumulation decreased and stimulation of microglial cells increased.
The latest study combining the two treatments showed a dramatic increase in plaque cleansing in the brain, including in the areas of cognitive functions such as learning and memory.
"These microglia pile up on top of each other around the plates," Tsai said.
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