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Researchers from the University of Cambridge published today in the journal Nature a study on an innovative technique to badyze the development of human placenta by laboratory cultures, which will increase the knowledge about diseases during pregnancy.
The process consists of creating organoidthat is to say, miniaturized models of an organ developed in the laboratory and allowing to better know the development of a placenta in gestation.
In this way, many disorders that appear during this process can be studied, such as preeclampsia, growth restriction, and fetal death, which are caused by abnormal growth of the fetus in the placenta during the first trimester.
Up to now the knowledge of the human placenta because of the lack of functional models created in the laboratory with which to experiment, the development of organoid will expand investigations in this area.
Scientists, led by University of Cambridge professor Ashley Moffett, have used long-term crop generation organoid created from trophoblastic cells extracted from the placenta during the first trimester, between six and nine weeks of gestation.
Cultures grew rapidly and they developed structures three-dimensional organoid During the first fifteen days, and even three randomly selected cultures continued to grow healthy after one year.
These organoid will also study the physiological, metabolic and hormonal changes that occur during pregnancy. the pregnancy. EFE
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