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A team of researchers discovers a pharmaceutical compound that hides cancer cells from Al-Maqtar proliferation, a team of researchers discovers a compound that prevents cancer cells from spreading. [1] The fight against cancer means killing cancer cells, but oncologists know that it is a disease It is also important to disrupt the movement of cancer cells before they spread throughout the body.
New research published in Nature Communications shows that cancer cells can be frozen and killed where they are. Raymond Bergan, Head of the Division of Hematology and Oncology, said: "Most of the ways to cure cancer nowadays are aimed at killing cancer." He said that to date, no one has developed treatment capable of disrupting cancer cells. Move around the body. "For most cancers, such as bad cancer, prostate, lungs, colon and other types, if detected early," says Pergan, who is also deputy director of medical tumors at the # OHSU Knight Cancer Institute and Director of the OHSU Bergan Laboratory for Basic Research. When a small block is in the member), and has not yet spread, you will live.
And in a year, if you discover late after the spread of cancer in your body, you will die. "
" Movement is key, they are the difference between black and white, night and day, and if cancer cells spread through your body, they will kill you, we can treat them, but that will cost you life. "
For this reason, studying the movement of cancer cells (movement capacity) has been the research focus of his group for several decades.
Defusing Cancer Cell Trafficking:
In 2011, Bergan and his team took a new approach to their research by working with chemists to discover a new drug that would inhibit cell movement cancerous. KBU2046, a compound that inhibits the ability of the cell to move in four models of different human bad cancer cells: bad cancer, prostate, colon and lung. Bergan said, "We used chemistry to explore biology, to give us an effective drug that would only inhibit the movement of cancer cells and nothing else, this fundamental shift in logic will lead us to do everything we want. "
Purification of Drugs:
Pergan pointed out that the special drug filtration process was a process of purification. "We started using a chemical that prevented the cells from moving, and then we refined the chemical, so that he did an ideal job of stopping the cells without any side effects," he says. All medications have side effects, so you should seek as much as possible of the highest quality drugs, and this medication does it. "
The main key of this drug is the use of heat shock proteins (cell cleansers).
The way the drug acts is to bind these cleaning proteins to stop the movement of the cell, but it has no other effect on these proteins because it's an unusual and rare way that it took us years to discover.
"Nobody would have funded us at the beginning, and we were looking for a completely different way to treat cancer. "
Next Step: Drug Testing in Humans:
In the end, Gordon says that Jull's research is essentially looking for a new cure for human benefit. "The hope of this research is that we are working to develop a therapeutic approach that can help manage the early stage of the disease to prevent patients from getting sick." to reach the stage irr eversible (intractable), "he said.
He quickly noticed that this work had not been tested on humans, that it would take time and money, and that, at best, the team would take about two years and would need $ 5 million.
They are currently raising funds to conduct IND INDDEPENDENT STUDIES, a requirement for a clinical trial of an unsupported drug, a certified product for a new presentation, or a new group of patients.
"Our ultimate goal is to be able to tell a woman with bad cancer:" Take this pill and your cancer will not spread in your body, the same for patients with cancer of the prostate, lung and colon.
This treatment is very effective in the laboratory up to now against four types of cancer (bad, colon, lung and prostate cancer), and our goal is to guide this as a treatment for the tests in humans. "
Bergan said that his team felt lucky to have the opportunity to carry out this difficult research at the OHSU Knight Cancer Institute, an institute dedicated to new approaches to detection and detection. Cancer Treatment.
"What early detection attempts to do is to detect early fatal injury, and the cancer is deadly because it's moving. This drug is designed to stop this movement," Pergan says.
This research was supported by the Department of Defense and the Veterans Administration
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