Can Aspirin Prevent Alzheimer's Disease?

Our Newspaper Does an Aspirin Tablet Treat Alzheimer's Disease Daily? Is it so simple?

A new study suggests that there is hope that aspirin – one of the most widely used drugs in the world – can help treat some aspects of the disease. Devastating Alzheimer's.

Scientists have discovered that aspirin works with a mechanism without specific atomic cells in the brain that prevents the formation of amyloid plaque and sticky spots of protein around brain cells, which is considered the primary cause of Alzheimer's disease, on mice.

Experiments in mice in the study revealed that aspirin stimulates the ability of lysosomes (which are somewhat similar to cells that treat and recycle cell debris) to clear or prevent amyloid plaques to train in the first place. "Aspirin should have the same effect on Alzheimer's disease as it does on humans," said researchers who published their findings on July 2 in the journal Neuroscience.

Alzheimer's disease is the most common type of dementia, an ascending cerebrovascular disease that affects nearly 6 million Americans, the sixth leading cause of death among all adults in the United States, according to the Centers for Disease Control and Prevention.

There is no cure, and the drugs have also achieved very limited success in slowing the progression of the disease.

Aspirin, also known as acetylsalicylic acid, is a reasonably priced drug that has been used safely in low doses for over a century, regardless of the condition. Possible gastric irritation and low risk of intestinal bleeding.

Many adults take a small dose of aspirin each day as a mild blood solvent to prevent heart attacks.

In fact, in a large-scale study on aspirin and heart health, aspirin has also been found to reduce the risk of Alzheimer's disease even moderately.

In March of this year, Chinese researchers badyzed meta-histology (badysis of a research result by incorporating the results of a number of independent research) into the journal Frontiers in Aging Neuroscience examining 18 studies at the population level. (NSAIDs), including aspirin, is badociated with a lower risk of developing Alzheimer's disease averaging 20%.

On the basis of the possible relationship between aspirin and Alzheimer's disease, researchers at the Rush University Medical Center in Chicago have prepared trials requiring aspirin for mice with Alzheimer's disease. Alzheimer's and aspirin directly on brain cells of rats. Laboratory.

"Both approaches, both in the body and in the laboratory, seem to prevent or reverse the biological signs of Alzheimer's disease," says Calibada Bahan, author of the main study and professor of neuroscience at Rush University.

Bahan explains: "Aspirin activates a cellular future called PPARα, which in turn regulates the protein (TFEB – the main regulator of lysosomal activity)."

In short, aspirin helps cells clear cellular debris that carry proteins forming amyloid plaques.

Bahan added to the magazine: Live Science "We expect to see the same results in the cells of the human brain."

In fact, other drugs such as gemfibrozil, which lowers triglycerides in the blood (also known as Lopid), control other TFEB proteins, but aspirin is sufficiently safe to be available without a prescription and has fewer side effects. "The recent study offers a large mechanical explanation of the protective effects of aspirin at the cellular level and animal models," said Rajini Rao, a professor of physiology at Johns Hopkins University in Baltimore who said: was not involved in the research.

However, she noted that the study did not determine whether the degree of improvement in amyloid effacement would result in better brain function.

The results of epidemiological studies on the use of aspirin for dementia are very different, Rau told Live Science magazine. While there are indications of protection, some studies do not fail to confirm it.

Unfortunately, this is the case of all drugs used in Alzheimer 's disease trials and more than 99% of them have not been successful in Alzheimer' s disease. ;apply. This is why research on Alzheimer's disease is a particular challenge. "Although aspirin is relatively safe, it is at risk when used daily, and should not be used as an unsupported way to treat or prevent Alzheimer's disease," Bahan said. Aspirin can also stimulate Lizosome activity.

PPARÎ ± receptors must exist, so that aspirin does not affect any patient with insufficient PPARÎ ± receptors, which explains the conflicting results of the study at the population level.

---

• Revise and Edit: Tasnim Almnajjid
• Source