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An ambitious project, led by the USC's Keck School of Medicine, will explore why African-American men are at greater risk of developing more aggressive forms of the disease and why they are more likely to die from her.
The Keck School of Medicine USC directs the first large-scale and multi-institutional RESPOND study, funded by grants from the National Cancer Institute, the National Institute of Physicians and Surgeons. disparities in health and minority health and the Prostate Cancer Foundation. He will examine the role of social stressors and genetics in the development of prostate cancer in African-American men. The researchers hope to recruit 10,000 African-American men across the country.
"Not only are African Americans twice as likely to develop prostate cancer, but they are more likely to have an aggressive and more deadly form of the disease – we do not know why." said the principal investigator of the project Christ opher Haiman ScD, professor of preventive medicine at the Keck School. "This is a health disparity that needs to be addressed.Many money, time and effort has gone into studies in men of European origin; time for a large-scale effort devoted to men of African descent. "
The RESPOND study will focus on the biological and social factors that may influence the development of prostate cancer in this group. Social stressors such as discrimination, socio-economic status, education, early life events and where men live will be evaluated via an online survey. Studies have shown that stress affects health, but it is not known if stress has an impact on the development of aggressive prostate cancer, explained Haiman
Men participating in the study will also need to provide a saliva sample and grant permission. for researchers to access their biopsy tissue from prostate cancer. The samples will be used to identify the genetic markers of prostate cancer and the characteristics of the tumor, with a particular focus on aggressive prostate cancer. All biological samples given will be used for research purposes only.
"We plan to examine the variations in DNA badociated with prostate cancer in general and, more importantly, the aggressive forms of lethal prostate cancer. These genetic markers will ultimately help us identify men in future generations who are at high and low risk for prostate cancer, "said Haiman,
Rutgers Cancer Institute of New Jersey . of New Jersey Cancer, New Jersey Department of Health, Institute of Public Health, Emory University Dana-Farber Cancer Institute / Harvard University Johns Hopkins University LSU New Orleans Health, Baylor College of Medicine Moffitt Cancer Center, Barbara Ann Karmanos Cancer Institute / Wayne State University and University of California, San Francisco .
Recruitment for the RESPOND study will begin in September 2018 .For more information on the study and how to participate, go to sponds study.org
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