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WASHINGTON • A team of researchers from the United States has identified a gene in mice that can reverse wrinkles and hair loss.
And the team said they believe the breakthrough that could be applied to humans in the future reports last week
"Wrinkled skin and hair loss are hallmarks of aging, and if they could be reversed? " researchers from the University of Alabama at Birmingham (UAB).
In the study, the mice received an antibiotic that caused changes in their gene. The antibiotic induced a mutation and mice developed wrinkled skin, and also suffered significant hair loss in a few weeks.
The mutation was caused by mitochondria – or structures functioning as the digestive system of the cell – becoming dysfunctional. 19659002] However, when mitochondrial function was reestablished, mice regained smooth skin and thick fur, indistinguishable from a healthy mouse of the same age.
"To our knowledge, this observation is unprecedented," said Dr. Keshav Singh. , Professor of Genetics at the UAB School of Medicine
When mitochondrial function was reestablished, the mice found a smooth skin and a thick fur, indistinguishable from a healthy mouse of the same age.
Dr. Singh said that the mouse model should offer the opportunity to develop preventive and therapeutic drug development strategies to increase mitochondrial functions in the treatment of age-related diseases and others. [19] 659002] In humans, there is a decline in mitochondrial function during aging and mitochondrial dysfunction may result in age-related diseases. Depletion of DNA in mitochondria is also badociated with human mitochondrial diseases, cardiovascular disease, diabetes, neurological disorders badociated with age and cancer.
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