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Directly from the dpa news channel
Heidelberg (dpa) – In the fight against resistant bacteria could already known, but with other substances aufgepeppte drugs help. Researchers led by Ana Rita Brochado of the European Molecular Biology Laboratory (Embl) in Heidelberg have demonstrated it impressively.
They tested in the laboratory how nearly 3000 different combinations of antibiotics and other agents act on bacteria. According to the researchers, it was the largest study of its kind so far, it was about fundamental interactions between the substances studied, and there is still a lot to do to find new therapies.
Antibiotic-resistant bacteria are not only a threat to immunocompromised people, According to the World Health Organization (WHO), about 500,000 new TB cases in 2016 mean that at least two antibiotics do not are more effective: 250,000 people die every year of TB-resistant pathogens. Also against pneumonia or urinary tract infections, common antibiotics often help. At the same time, it is becoming increasingly difficult for researchers and the industry to develop new weapons against bacteria.
The international team combined a total of 79 substances – including antibiotics, other drugs and nutritional supplements – into pairs. Next, the researchers examined how three types of bacteria reacted to mixtures. It is known that Pseudomonas aeruginosa, Escherichia coli and Salmonella typhimurium very often develop resistance to antiobiotics
. Result: Most badociations tested tend to reduce the antibiotic effect. In over 500 cases, however, there was a reinforcing effect, as the researchers in the review
Nature report. Some mating has also been tested on multidrug-resistant bacteria and has shown a positive result.
The researchers were particularly struck by the combination of the antibiotic spectinomycin and vanillin. The aroma ensures that spectinomycin penetrates the bacterial cell more easily and stops growth. The antibiotic was developed in the early 1960s to combat venereal gonorrhea, also known as gonorrhea. Today, however, the remedy is no longer used because the bacteria have become resistant. In combination with vanillin, spectinomycin may return. On the other hand, aromatization had a counter effect on other antibiotics.
The researchers point out that many more tests and clinical trials are needed to study the effects of drug mixtures on humans
. The results of the non Heidelberg researchers, as the infectiologist Winfried Kern highlights the University Hospital of Freiburg. "The results are best known and have already been published several times in a similar form," notes Kern, who has not been involved in the study. The discovery that vanillin and spectinomycin activate one another, but vanillin leads rather to greater antibiotic resistance, is interesting.
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