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Can a special diet improve the treatment of cancer?
Researchers have now discovered that a so-called ketogenic diet seems to eliminate the side effects of a new generation of anticancer drugs. This could help improve the treatment of cancer patients.
Researchers at the Meyer Cancer Center have discovered in their current research that the keto diet can reverse the side effects of a new clbad of anticancer drugs. The doctors published the results of their study in the English magazine "Nature".
New anti-cancer drugs target a specific molecular pathway
In recent years, scientists have tested a new clbad of anti-cancer drugs. These target a specific molecular pathway that has proven to be defective in many types of cancer. In particular, these drugs target a cellular signaling pathway known as phosphatidylinositol-3-kinase (PI3K), which is activated by insulin. Previous studies have already shown that mutations in this kinase or this enzyme are present in most tumors.
New drugs with strong side effects up to now
A total of more than 50 drugs have been developed in order to inhibit this pathway. clinical trials have tested their effectiveness, experts say. Until now, however, the results of these experiments have been relatively disappointing. In most cases, the effectiveness of the drugs was low or their toxicity was too high, say the doctors.
Taking medication often causes hyperglycemia
Taking these medications often leads to hyperglycemia or abnormally high blood sugar levels. This happens because the inhibition of the pathway causes the fall of insulin, which increases blood sugar levels, explain the researchers. If the pancreas is unable to compensate for the loss by producing more insulin, patients should stop taking the drug. The new study may now have found a way around this problem.
Keto diet improves the efficiency of the new generation of therapies
The keto diet is currently very fashionable. It includes a diet high in fat but very little carbohydrate. A ketogenic diet could be the best way to increase the effectiveness of this new generation of therapies and to avoid its side effects, explain the authors of the study. (As)
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