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Risk of implanted lung cancer linked to the donor's lung
Specialists have recently examined a sad case from France. According to the medical report, a 39-year-old French woman received a new lung, suffering from cystic fibrosis since childhood. The donor organ came from a 57-year-old smoker who consumed 20 cigarettes a day for 30 years. Two years after the transplant, the woman suffering from serious pulmonary problems was admitted to the University Hospital of Montpellier. Lung cancer was diagnosed in the non-smoker. She died two months later.
A group of French experts reported in a report on the risks badociated with long-term donations of smokers. They investigated the case of a non-smoker who died of lung cancer after using the lungs of a smoker. The report was recently published in the journal "Lung Cancer".
The donor was a heavy smoker
A 39-year-old woman was admitted to the oncology department of Montpellier University Hospital. Due to cystic fibrosis for life, she suffered from constant breathing difficulties and her respiratory capacity decreased. Finally, in November 2015, a double lung transplant was performed. The donor registry indicates that the donor's lung was from a 57-year-old woman who smoked 20 cigarettes a day for 30 years. The organ was thoroughly examined by computer tomography to detect the presence of lung foci before transplantation.
Two years later, fate is on its way
First, the patient's condition has improved. Barely two years later, she was again admitted to the hospital. She was suffering from a high fever and severe shortness of breath. Doctors have diagnosed a particularly aggressive form of lung cancer. The tumor grew so fast that it doubled every 28 days, the doctors reported. It's much shorter than usual observed. Normally, the doubling rate for this type of tumor is about 600 days.
The woman with the organ of the donor had no chance
In a short time, several cancer foci have formed in the lungs and many metastases. Therapies have no chance of success. The woman died two months later as a result of lung cancer.
Mutation while smoking
Tumor DNA badyzes revealed that a particular genetic mutation was responsible for rapid growth. This mutation is usually badociated with smoking only. Professor Jean-Louis Pujol and his colleagues badyzed the case. They conclude that the immunosuppressive drugs that the patient should take after the transplant are probably responsible for the accelerated growth.
Should not smokers' lungs be released for donations?
The report concludes that given the long latency period of lung cancer, it is not recommended to transplant a lung of long-term smokers, especially those who have recently quit smoking. (Vb)
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