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What is the cause of diabetes medications in Alzheimer's disease?
People with Alzheimer's disease could benefit from treatment with cheap drugs for diabetes. Researchers have now discovered that antidiabetic drugs can reduce the severity of Alzheimer's disease.
Scientists at Mount Sinai's Icahn School of Medicine have discovered in their recent research that the use of antidiabetic drugs can help people with Alzheimer's disease. The doctors published the results of their study in the English magazine "PLOS ONE".
Do diabetes medications protect blood vessels in the brain?
The experts sought to understand why Alzheimer's patients with type 2 diabetes had less accumulation of protein in their brains. To do this, they examined the tiny blood vessels in the brains of people with both diseases. When patients took antidiabetic drugs, their brains were in better shape. Scientists suspect that insulin and metformin drugs, which help regulate blood sugar, also preserve blood vessels in the brain. This could prevent the presence of toxins causing dementia, speculate the researchers. For their study, the researchers badyzed the brain of 34 Alzheimer's patients also treated for type 2 diabetes. In addition, 30 non-diabetics with Alzheimer's disease and 19 non affected with the disease have been studied.
Results could lead to more targeted treatment
The findings do not mean that people without type 2 diabetes should start using antidiabetic drugs to protect themselves from Alzheimer's disease, said Professor Vahram Haroutunian, author of the study, of Mount Sinai Medical School Icahn. The findings could lead to more targeted treatment of patients with Alzheimer's disease in the future. The published study is hopeful, as diabetes medications could also reduce the severity of Alzheimer's disease. Alzheimer's disease is a progressive and degenerative brain disease, characterized by the accumulation of abnormal proteins and death of nerve cells.
Additional research is needed
Professor Haroutunian states that most modern treatments for Alzheimer's disease target so-called amyloid plaques but still do not result in effective treatment of the disease. Medications for diabetes can reduce the abnormalities of blood vessels in Alzheimer's disease, which can help prevent toxins and introduce important nutrients. Additional studies should now be conducted on people using similar drugs. In addition, the authors of the study should also study further drugs that have similar effects on the biological pathways and brain cell types identified in this study. (As)
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