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Rhinitis Diseases: The World's Largest Genetic Allergy Cold Study
In a new study of allergic rhinitis, researchers identified 20 previously unknown risk genes. According to experts, this accounts for about eight percent of allergic rhinitis diseases
The most common form of allergy
Nearly one-third of German adults and about one in four suffer from pain. allergies. Allergic rhinitis (in jargon called allergic rhinitis) is the most common form of allergy. An international team of scientists led by the Helmholtz Zentrum München and the University of Copenhagen presented the largest study ever done on allergic rhinitis. Data from nearly 900,000 participants revealed sites in the human genome whose changes significantly increase the risk of disease.
About 400 million people affected in the world
Allergic rhinitis includes several clinical pictures generally triggered by allergens in the air
including colds Hay. the mite of house dust and allergy to animal hair.
As the Munich Helmholtz Center writes in a statement, about 400 million people worldwide are affected by the disease, especially in Western countries. First and foremost, we need to understand why the body is defending itself against some really harmless substances, "says Dr. med. Marie Standl, head of working group at the Institute of Epidemiology Helmholtz Zentrum München
The first author of this book, published in the journal "Nature Genetics", played a decisive role in the 39 statistical badysis of data from nearly 900,000 people. Genetic differences between people with and without allergic rhinitis
The purpose of the EAGLE research collaboration (Early Genetics and Lifecourse Epidemiology) was to identify genetic differences between people with and without allergic rhinitis.
The researchers compared this in the first The genetic makeup of about 60,000 patients with allergic rhinitis was compared to that of more than 150,000 healthy controls and identified a group of 42 genes at significant risk, some of which have already been described in the literature
. confirm data from another 60,000 affected people and 620,000 healthy controls.
"The higher the number of participants in the study, the more reliable the statement we can make," says Standl. "Because of the known risk, genes can be explained in about eight percent of allergic rhinitis diseases."
Not clearly understood why so many people develop allergic rhinitis
Subsequently, scientists have examined the databases
According to experts, for most of them a connection to the immune system was already known, including antigen binding.
In addition, a strong overlap of genes at risk for allergic rhinitis and autoimmune diseases has been observed. "The sites in the genome identified by us promote understanding of the mechanisms of allergic colds and we hope to open new target structures for its treatment and prevention," says Dr. med. Klaus Bønnelykke
He led the study with his colleagues Johannes Waage and Hans Bisgaard of Copenhagen Prospective Studies on Asthma in Childhood, COPSAC for short, at the University of Copenhagen
"However, the genes found only partially explain why so many people develop allergic rhinitis.An important next step will be to explore the interaction of risk genes and the environment" said the expert. (Ad)
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