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Unpleasant surgical aftereffects: If anyone has a tendency to nausea after anesthesia or not, also depends on the genes. Researchers have identified a gene variant that makes their carriers more sensitive to this typical anesthetic effect. This gene effect is independent of other risk factors – and explains why even patients with a supposedly low risk of nausea suddenly vomit.
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During anesthesia, a combination of anesthetic and badgesic drugs puts us in a state of unconsciousness during surgery, allowing us to lull even painful procedures.But for some people, there is an unpleasant awakening: they have severe nausea after waking up anesthesia.
Nausea Despite Low Risk Factors
"Preventive measures are often taken to reduce the frequency of postoperative nausea" Stefanie Klenke of the University of Duisburg-Essen Anesthesiologists i question their patients about possible risk factors such as anesthetic anterior compatibility, smoker status and the tendency to motion sickness. Sex also plays a role in the subsequent clbadification according to the so-called apple score
Strange, however: Again and again patients who have a low apple score and are therefore low risk for this side effect are unequal after Surgery, Researchers have long suspected a particular gene variant in the M3 acetylcholine receptor.
Crucial Gene Variant
Whether correct, Klenke and his colleagues have now checked with 454 subjects who were about to undergo a planned operation. According to a genetic test, 191 of these patients carried the normal gene variant GG, 207 variant mixed A and 56 participants the sequence of DNA altered AA. The researchers then examined the extent to which this affected nausea after anesthesia.
The result: The carriers of GA and AA gene variants were significantly more likely to experience anesthetic nausea. Their relative risk was 50 to 60% higher than that of carriers of the GG gene variant, as reported by the researchers. The decisive factor was that this risk was completely independent of the apple score and previously known risk factors for anesthetics.
In the future, genetic testing before anesthesia
Therefore, researchers recommend their colleagues to play safety. Patients with preventive measures should also be protected against nausea, which, according to Apple's score, are only expected to present a low risk. In the future, a genetic test could also help identify these high-risk patients
"If the gene variant is present, these patients should also be treated for postoperative nausea," says Jürgen Peters, colleague of Klenkes. "However, these genetic screens are currently not performed." (British Journal of Anesthesia, 2018, doi: 10.1016 / j.bja.2018.02.025)
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