[ad_1]
This is one of the biggest health problems: bacteria, which almost no antibiotic can harm. New active ingredients must be produced. Or is not it?
In the fight against already known resistant bacteria, but with other substances aufgepeppte drugs could help. Researchers led by Ana Rita Brochado of the European Molecular Biology Laboratory (Embl) in Heidelberg have demonstrated it impressively.
They tested in the laboratory how nearly 3000 different combinations of antibiotics and other agents act on bacteria. According to the researchers, it was the largest study of its kind so far, it was about fundamental interactions between the substances studied, and there is still a lot to do to find new therapies.
Antibiotic-resistant bacteria are not only a threat to immunocompromised people, According to the World Health Organization (WHO), about 500,000 new TB cases in 2016 mean that at least two antibiotics do not are more effective: 250,000 people die every year of TB-resistant pathogens. Also against pneumonia or urinary tract infections, common antibiotics often help. At the same time, it is becoming increasingly difficult for researchers and the industry to develop new weapons against bacteria.
The international team combined a total of 79 substances – including antibiotics, other drugs and nutritional supplements – into pairs. Next, the researchers examined how three types of bacteria reacted to mixtures. It is known that Pseudomonas aeruginosa, Escherichia coli and Salmonella typhimurium very often develop resistance to antiobiotics
. Result: Most badociations tested tend to reduce the antibiotic effect. In more than 500 cases, however, there was a strengthening effect, as reported by the researchers in the journal "Nature". Some couples have also been tested in multidrug-resistant bacteria and have shown a positive result.
The researchers particularly noted the combination of the spectinomycin antibiotic and vanillin. The aroma ensures that spectinomycin penetrates the bacterial cell more easily and stops growth. The antibiotic was developed in the early 1960s to combat venereal gonorrhea, also known as gonorrhea. Today, however, the remedy is no longer used because the bacteria have become resistant. In combination with vanillin, spectinomycin may return. In other antibiotics, however, the aroma had the opposite effect.
Our PDF Guide shows you the top ten tips and the most effective remedies for hemorrhoids. point out that many more tests and also clinical studies are needed to study the effects of drug mixtures on humans.
The results of the Heidelberg researchers are not completely new, as underlined by the infectiologist Winfried Kern of the University Hospital of Freiburg. "The results are best known and have already been published several times in a similar form," notes Kern, who has not been involved in the study. The discovery that vanillin and spectinomycin activate one another, but vanillin leads rather to greater antibiotic resistance, is interesting.
Source link
