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A team of scientists from the Max Planck Institute for Metabolism Research at Kln has deciphered how obesity promotes the development of colorectal carcinomas: In the intestine, immunocompromising cells are developed to support tumor growth. The researchers found that it was Dr. Claudia Wunderlich in the surveys with ideas and reports about it in the journal Nature Communications.
Overweight and unfavorable eating habits are known risk factors for the development of colorectal cancer. Wunderlich researchers have now examined the detailed relationships of this phenomenon in a mouse model for colitis, where animals have either been fed normal foods or have been fat-fed through a high-fat diet. The latter increased inflammation in the large intestine and increased the barrier function of the intestine. In particular, the pro-inflammatory cytokine IL-6 was more and more released. In the intestine, this eventually led to reprogramming of macrophages. These immune cells can adopt two different phenotypes with different properties: M1 macrophages are cytotoxic and pro-inflammatory and able to fight cancer cells. The second M2 phnotype is rather pro-regenerative and has angiogenic, growth-promoting and immunomodulatory properties that a tumor can exploit.
IL-6 signals produced more M2 macrophages in the experiment. These in turn attracted special B and T cells into the colon tissue via the CCl-20 messenger substance, further promoting tumor growth, the researchers report. The team was able to identify new targets for possible therapeutic approaches in humans with the IL-6 signaling pathway and the recruitment of CCL-20-related immune cells. . (Ch)
DOI: 10.1038 / s41467-018-03773-0
More on cancer and cytostatics
17.07.2018 l PZ
Photo: Fotolia / Mirko Raatz
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