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According to the Federal Statistical Office, heart failure is one of the leading causes of death in Germany. People suffering from hypertension or diabetes are particularly at risk. Rabea Hinkel wants to find out how these risk factors are affecting heart failure and want to develop new therapies. The veterinarian, specialist in cardiology, is a professor in zootechnics since July 2018, appointed jointly by the University of Veterinary Medicine of Hanover (TiHo) and the German Primate Center (DPZ), where she runs the department of the same name. In her inaugural lecture entitled "Translational Research in Cardiology – A Real Affair of the Heart", Rabea Hinkel spoke about her contribution to research on the development of new therapeutic approaches for heart disease. The public event will take place on Monday 19 November 2018 at 17.15 in the conference room of the German Primate Center, Kellnerweg 4, Göttingen. Visitors are welcome.
The heart is the vital engine of our blood circulation. It beats about 60 to 80 times a minute, more often when it is exercised. A reduction in pumping capacity results in less blood and therefore less oxygen and nutrients transported into the body. This results in decreased physical performance, fatigue, shortness of breath, water retention and, in the advanced stages of the disease, damage to other organs such as the liver, kidneys or digestive tract. and, finally, cardiac death. Heart failure is difficult to treat and in most cases requires a heart transplant. High-risk patients with hypertension, diabetes, or high blood lipid levels are at risk. It's there that intervenes Rabea Hinkel's research.
"With my research, I would like to intervene preventively and develop new therapeutic approaches for at-risk groups," said Rabea Hinkel. "For that, I would like to establish a model of heart failure in non-human primates in the next few years." Monkeys are particularly well suited for this because their cardiovascular system is very similar to that of humans. In collaboration with his current nine-member team, Hinkel wants to develop a functional treatment model and bring it to preclinical research so that it can be used for the patient in the future.
Hinkel does not only provide for close interdisciplinary cooperation within the DPZ, it has also initiated collaborations with the University Medical Center Göttingen and the Max Planck Institute for Dynamics and Self-organization. "The Göttingen site is well positioned and networked in the field of cardiology and therefore offers me ideal conditions to promote this line of research," said Rabea Hinkel.
The development and improvement of experimental animal research will be the focus of Hinkel's work at TiHo Hannover. "We will focus on finding alternative methods and supplementation for animal testing," she says. "We will not only use in vitro experiments, but also develop them further, my goal is to reduce the burden of animals as much as possible and to replace more and more experiments with alternative methods." Hinkel will work closely with the Institute's "Experimental Animals" working group for Animal Hygiene, Animal Welfare and the Ethics of Animal Husbandry. directed by Bernhard Hiebl,
Rabea Hinkel first studied veterinary medicine at Justus Liebig University in Gießen. Subsequently, the Dillenburg native joined the Faculty of Internal Medicine at the Ludwig Maximilian University (LMU) in Munich, where she obtained her Ph.D. in 2009. Postdoctoral and veterinary researcher for research on laboratory animals , Rabea Hinkel first worked at the Munich LMU before moving to Internal Medicine at the Klinikum Rechts der Isar of the Technical University and at the Institute of Disease Prophylaxis and Epidemiology. Cardiovascular of the LMU. In 2017, she received a start-up grant from the European Research Council to study the effects of diabetes on the small blood vessels of the heart muscle. His research goal, heart failure in various animal models and his close connection with clinical application, will be faithful to Göttingen.
scientific contact:
Teacher. Dr. Rabea Hinkel
Phone: +49 (0) 551 3851-241
E-mail: [email protected]
idw 2018/11
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