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Diabetics have a significantly increased risk of developing cancer as metabolic health. This is especially true for women, as shown by a meta-badysis of nearly 20 million diabetics worldwide, which has now appeared in the journal Diabetologia. Scientists from Camperdown, Australia, and Oxford, UK, evaluated data from 121 cohorts of nearly 20 million diabetic patients, of whom more than one million had cancer.
The calculation of Dr. med. According to Toshiaki Ohkuma and colleagues, women with diabetes are 27% more likely to have cancer than women without a metabolic disorder. For men with diabetes, the risk is increased by 19 percent. Diabetics have a 6% higher risk of cancer than diabetics. In particular, the risk of renal, oral, gastric and leukemic tumors was higher in patients than in men. Only liver cancer was less common in diabetic women than in men.
The results showed that the relationship between diabetes and cancer needs to be further explored – especially with respect to gender differences, according to a press release from the institute. That diabetics have an increased risk of cancer, is now well documented. For reasons to this, various factors are discussed. First, the increase in blood sugar could cause damage to the DNA, directly or indirectly, through oxidative stress. On the other hand, the increase in insulin secretion in the prediabetic phase, with which the body tries to thwart the onset of insulin resistance, could contribute to tumor growth via the proliferative effect of insulin.
The fact that women with diabetes are more likely to develop cancer than men may be due to the fact that women would be worse off than men, according to the publication. As a result, hyperglycemia can have a stronger effect on them. In addition, the prediabetic phase lasts an average of two years longer in women than in men. This means that they are more exposed to untreated hyperinsulinemia. (Ch)
DOI: 10.1007 / s00125-018-4664-5
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20.07.2018 l PZ
Photo: Fotolia / M & S Photography
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