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Washington: An experimental process of freezing testicular tissue gives young boys hope to preserve their fertility before starting medical treatments known to cause infertility, according to research. The study was published in the journal & # 39; Human Reproduction & # 39 ;.
It is estimated that each year about 2,000 American boys and young men receive treatment or have cancer or blood disorders that put them at risk for infertility. While older youth who have experienced puberty may retain their sperm before receiving sterilizing doses of chemotherapy or radiation therapy, fertility preservation options are rare for younger boys.
However, some older adolescents and young men are too sick or too stressed to keep their sperm in the bank. For patients who do not have sperm in a bank or who are too sick or too stressed to sperm in a bank, the experimental procedure of freezing testicular tissue by anticipating that future treatments based on cells or tissues can generate sperm is the only option possible.
Recent research on experimental models indicates that such testicular tissue biopsies contain stem cells, blank slate cells, suggesting the potential for sperm generation from biopsied tissue.
"This study demonstrates that undifferentiated spermatogonia of strains and progenitors can be recovered from the testicular tissues of patients at the start of treatment and have not yet received ablative treatment." not been tested, "he writes. Lead author Hanna Valli-Pulaski, Research Assistant Professor at the University of Pittsburgh.
At present, hematologists and oncologists are discussing future treatment options with patients and their families, as well as possible long-term side effects, including infertility.
"This study is unique in that there is definitely a direct benefit to the patient. One of the reasons she is convincing is that she presents a message of hope to families. It is a message of survival: we are optimistic and we can help your child. Think about it and think about long-term issues, such as having their own family, "said Michael Hsieh, director of transitional urology at Children's National.
During this phase of the study, testicular tissue was collected at centers in the United States and Israel from January 2011 to November 2018 and then cryopreserved.
Patients designated 25% of the tissue sample to be used for the research study; 75% remain stored in liquid nitrogen at temperatures near absolute zero for future use of the patient. Fertility-preserving patients ranged in age from 5 months to 34 years, with an average age of 7.9 years.
Thirty-nine percent of patients had started medical treatment before applying for fertility preservation. 16% received non-alkylating chemotherapy, while 23% received alkylating chemotherapy, which directly damages the DNA of cancer cells.
Washington: An experimental process of freezing testicular tissue gives young boys hope to preserve their fertility before starting medical treatments known to cause infertility, according to research. The study was published in the journal & # 39; Human Reproduction & # 39 ;.
It is estimated that each year about 2,000 American boys and young men receive treatment or have cancer or blood disorders that put them at risk for infertility. While older youth who have experienced puberty may retain their sperm before receiving sterilizing doses of chemotherapy or radiation therapy, fertility preservation options are rare for younger boys.
However, some older adolescents and young men are too sick or too stressed to keep their sperm in the bank. For patients who do not have sperm in a bank or who are too sick or too stressed to sperm in a bank, the experimental procedure of freezing testicular tissue by anticipating that future treatments based on cells or tissues can generate sperm is the only option possible.
Recent research on experimental models indicates that such testicular tissue biopsies contain stem cells, blank slate cells, suggesting the potential for sperm generation from biopsied tissue.
"This study demonstrates that undifferentiated spermatogonia of strains and progenitors can be recovered from the testicular tissues of patients at the start of treatment and have not yet received ablative treatment." not been tested, "he writes. Lead author Hanna Valli-Pulaski, Research Assistant Professor at the University of Pittsburgh.
At present, hematologists and oncologists are discussing future treatment options with patients and their families, as well as possible long-term side effects, including infertility.
"This study is unique in that there is definitely a direct benefit to the patient. One of the reasons she is convincing is that she presents a message of hope to families. It is a message of survival: we are optimistic and we can help your child. Think about it and think about long-term issues, such as having their own family, "said Michael Hsieh, director of transitional urology at Children's National.
During this phase of the study, testicular tissue was collected at centers in the United States and Israel from January 2011 to November 2018 and then cryopreserved.
Patients designated 25% of the tissue sample to be used for the research study; 75% remain stored in liquid nitrogen at temperatures near absolute zero for future use of the patient. Fertility-preserving patients ranged in age from 5 months to 34 years, with an average age of 7.9 years.
Thirty-nine percent of patients had started medical treatment before applying for fertility preservation. 16% received non-alkylating chemotherapy, while 23% received alkylating chemotherapy, which directly damages the DNA of cancer cells.
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