Fat in the soil Bacteria can make you less subject to stress

One last discovery could help explain why living with land can be good for human health. Scientists have discovered that a bacterium that breathes in the soil creates an anti-inflammatory fatty acid that can promote stress resilience.

Individuals from the University of Colorado (CU Booulder) led a research project Mycobacterium vaccae, bacterium found in the environment that deals with decomposing organic matter.

Previous research with the help of cells and laboratory animals revealed that Mycobacterium vaccae can reduce inflammation and avoid stress.

Despite this, the writer clarifies in a recent psychopharmacology article on their work, "the essential molecular mechanisms of the aniti-inflammatory effects of Mycobacterium vaccae are not recognized. "

In current research, researchers have "filtered and spotted a unique anti-inflammatory triglyceride" in the soil bacterium. They then synthesized and examined the register of "free fatty acids" in fat in mouse immune cells.

The fatty chemical carries the 10 (Z) -hexdecagon acid label and the group used "new generation sophisticated sequencing methods" to examine its interaction with macrophages, a clbad of immune cells.

The investigators found that the fatty acid is bound to a particular receptor or protein in the cells. In turn, this has obstructed a number of molecular pathways inducing inflammation. Title given to peroxisome proliferator-activated receptor receptor (PPAR).

In addition to the investigation conducted by the researchers showed that exposure of immune cells to the fatty acid before stimulating them increased their strength against inflammation.

The soil bacterium has a direct and secure effect

Christopher Lowry, Professor of Integrative Physiology at CU Bolder, said: "We anticipate that there is a unique sauce that ensures the secure effects of this bacteria and that this fat is one of the essential ingredients of this remarkable sauce. "

He also states that the discovery of this information is "a big step forward for us to develop because it is an energetic component of the bacterium and the receptor of this living component of the host".

The conciliation between anti-inflammatory acid and immune cells is a creation of the co-evolution of man and soil bacteria. Lowery argues that macrophages are immune cells that separate pathogens, such as bacteria, by consuming them. They occupy a central place in inflammation.

According to Lowery, it appears that just as the soil bacterium attaches to immune cells, it exerts the anti-inflammatory chemical properties. This is more related to PPAR and closes the "inflammatory cascade".

Research shows that contact with soil bacteria is beneficial to human health in unique ways compared to what scientists think.

Another aspect of the effect of hygiene

Referring to some previous years, scientists have been able to identify few events at the molecular level in cells. All they have been able to prove is that exposure to microorganisms would be beneficial to health.

The research done by the British scientist David Strachan to qualify the term "hygiene" hypothesis in 1989.

The theory explains that the more the modern lifestyle of individuals moves them away from land animals and farm animals, so that their intestines miss the microorganism, which causes other problems, such as immune system damage. and an increased threat of allergy and asthma.

In addition, surveys such as Lowry and his companions are trying to make changes to explain the hygiene hypothesis so that the person is aware of another aspect of the story. of co-evolution.

Lowry tells people that their research is exploring the "tip of the iceberg in terms of badyzing the mechanisms by which soil bacteria have been transformed to keep us healthy."