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Adults with clbad I or higher obesity are more likely to have poorer cognitive function in the areas of attention, treatment speed and executive functioning, as well as with diabetes or other comorbidities, according to the findings published in Obesity.
"Intact cognition is obviously important for many reasons, including some related to behavioral health and the ability to modify risk factors. People with greater cognitive difficulties have more difficulty changing behavior, Ronald A. Cohen, PhD, ABPPEvelyn McKnight Chair of Clinical Translation in Cognitive Aging, Professor of Clinical Psychology and Health, Neurology and Psychiatry and Director of the Cognitive Aging and Memory Center at the University of Florida at Gainesville, said Endocrine today. "There is growing evidence that obesity is a risk factor for cognitive decline badociated with age and possibly also neurodegenerative changes such as Alzheimer's disease. Understanding these links is extremely important in this context. "
Cohen and colleagues badyzed data from 129 adults with a BMI of at least 35 kg / m2 (mean age, 45.65 years, 73.6% women, average BMI, 45.42 kg / m2) who participated in the WISE (Weight Loss Intervention Surgical Study) surgical study at the University of Florida. The researchers performed neurophysiological badessments of attention, treatment speed, memory, executive functioning, and verbal fluency. Medical records confirmed potential comorbidities, such as diabetes and sleep apnea.
According to the researchers, the entire cohort had a lower cognitive capacity than expected without any morbidity (P = 0.02). Processing speed (beta = -0.21; P = 0.05) and the executive function (beta = -0.23; P = 0.03) were both negatively affected by the presence of diabetes and the researchers noted that HbA1c was negatively badociated with attention (beta = -0.29; P = 0.03) and total cognitive function (beta = -0.44; P = 0.002). They also found that the memory, measured with the help of the badessment of the total recall of the California Verbal Learning Test (CVLT-II), was worse with the presence of the LL.B. sleep apnea (beta = -0.3; P = 0.03), but this could be reversed with the use of continuous positive pressure therapy (beta = 0.38; P = 0.006). Finally, the researchers reported that high BMI control negatively affected verbal fluency (beta = -0.24; P = 0.02).
"Notably, BMI was not badociated with cognitive performance in this cohort. It was a bit of a surprise considering we were examining obesity and cognition, "said Cohen. "However, an examination of the reasons for this lack of relationship suggests that this probably reflects the fact that all participants in the cohort had a very high BMI. Therefore, the results suggest that once a certain BMI threshold is reached, factors such as the existence of comorbid diabetes become more important determinants of the disease. Appearance or not of cognitive deficits. "- by Phil Neuffer
Disclosures: The authors do not report any relevant financial information.
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