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Irvine, Calif., June 5, 2019 – Nanotechnology derived from bone marrow stem cells has reversed the symptoms of multiple sclerosis in mice and could eventually be used to help humans, according to a new study by researchers in the United States. University of California at Irvine.
"Until now, stem cell therapies for autoimmune and neurodegenerative diseases have yielded mixed results in clinical trials, in part because we do not know how the treatments work," said the researcher. Corresponding author Weian Zhao, Associate Professor of Pharmaceutical Sciences and Biomedical Engineering affiliated with Stem Cell Research Center Sue & Bill Gross. "This study helps solve this mystery and paves the way for testing on human patients."
In previous experiments, intravenously injected stem cells – derived from the bone marrow and activated with interferon gamma, a protein of the immune system – were often trapped in filter organs before reaching their target. For this study, published in the journal ACS Nanoresearchers have avoided this problem by extracting nanoparticles called exosomes from stem cells and injecting them into rodents with MS.
Loaded with RNA and anti-inflammatory and neuroprotective protein molecules, the exosomes were able to slide across the blood-brain barrier. In addition to rejuvenating lost motor skills and reducing nerve damage caused by MS, they have normalized the immune system of subjects, something that conventional drugs can not do, said co-principal author of the Study, Reza Mohammadi, PhD student in Materials Science and Engineering.
Other experiments are in progress.
"This new treatment will be tested on humans in early 2020, initially on people with type 1 diabetes," said co-lead author Milad Riazifar, who worked on the study as a PhD student. in pharmacological sciences in Zhao's laboratory and is currently involved in the preparation of the project. a clinical trial of the method by City of Hope. "If successful, this could pave the way for the treatment of other autoimmune diseases, including multiple sclerosis."
The other UCI researchers involved were Egest J. Pone, Aude I. Segaliny, Laura L. McIntyre, Ashley Hamamoto, Erika N. Calle, Wenbin Liao, Victor Pham, Jayapriya Jayaraman and Jonathan RT Lakey and Craig M. Walsh . Support was provided by the National Institutes of Health, a Training Grant from the National Institute of Neurological Disorders and Stroke, an Otto W. Shaler Fellowship and the French ARC Foundation for Cancer Research. .
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About the University of California at Irvine: Founded in 1965, the UCI is the youngest member of the prestigious Association of American Universities. The campus has produced three Nobel laureates and is known for its academic achievements, leading research, innovation and anteater mascot. Led by Chancellor Howard Gillman, the UCI has more than 36,000 students and offers 222 degree programs. Located in one of the safest and most economically vibrant communities in the world, it is the second largest employer in Orange County and contributes $ 5 billion a year to the local economy. For more information on UCI, visit http: // www.
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