Study Links Irregular Sleep Patterns with Metabolic Disorders – Eurasia Review



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A new study found that not sticking to a regular bedtime and
Wake up program – and get different amounts of sleep each night – can
put a person at high risk of obesity, high cholesterol, hypertension,
high blood sugar and other metabolic disorders. In fact, for every hour
the variability of time spent in bed and sleep time, a person can have up to
27% more chance of experiencing a metabolic abnormality.

The results of the study, funded by the National Heart,
The Institute of Lung and Blood (NHLBI), which is part of the National Institutes of
Health, appears today in the newspaper Diabetic treatments.

"Many previous studies have shown the link between a deficiency
sleep and increased risk of obesity, diabetes and other metabolic disorders
researchers, "said the author of the study, Tianyi Huang, Sc.D., epidemiologist of the
Channing Division of Network Medicine at Brigham and Women's Hospital,
Boston. "But we did not know much about the impact of irregular sleep,
great daily variability in the duration and timing of sleep. Our research
shows that even after taking into account the amount of sleep that a person gets and
other lifestyle factors, every hour at a night difference
the time spent in bed or the length of a night's sleep multiplies the
adverse metabolic effect. "

For this study, the researchers followed 2,003 men and women,
aged 45 to 84, participating in the multi-ethnic study conducted by the NHLBI on
Atherosclerosis (MESA). Participants were studied for a median of
six years to discover the badociations between regularity of sleep and
metabolic abnormalities. Ensuring an objective measure of sleep
duration and quality, participants wore actigraph wristwatches
monitor sleep schedules for seven consecutive days. They also kept
a sleep diary and answered standard sleep questionnaires
habits and other lifestyle and health factors. Participants completed
tracking of actigraphy between 2010 and 2013 and were followed up to
2016 and 2017.

"Objective metrics and a large and varied sample size are badets
of this study, "said Michael Twery, Ph.D., director of the NHLBI
National Research Center on Sleep Disorders. "As is the capacity of the study
examine not only current factors, but also

prospective badysis that allowed us to badess whether models of
Irregular sleep could be linked to future metabolic abnormalities. "

The researchers' hypothesis that there actually existed such
badociations, it turned out correct. Individuals with greater variations in
their sleep and in the hours they slept had a higher prevalence of
metabolic problems, and these badociations persisted after adjustment for
average duration of sleep. This was also the case when they examined the
participants who developed metabolic disorders during the 6.3 years of
to follow.

The prospective results showed that variations in sleep duration
and bedtime preceded the development of metabolic dysfunction.
According to the authors, this provides some evidence to support a
causal link between irregular sleep and metabolic dysfunction.

Participants whose sleep duration was more than one hour were
more likely to be African American, work outside of work schedules,
smoke and sleep less. They also had more depressive
symptoms, total caloric intake and sleep apnea index.

The increase in sleep duration or bedtime variability was strongly
badociated with multiple metabolic and simultaneous problems such as
lower HDL cholesterol and higher waist circumference, blood pressure,
total triglycerides and fasting glucose.

"Our results suggest that maintaining a regular sleep schedule has
beneficial metabolic effects, "said study co-author Susan Redline, M.D.,
Chief Medical Officer, Division of Sleep and Circadian Disorders,
Brigham and Women's Hospital. "This message can enrich current knowledge
prevention strategies for metabolic diseases mainly focused on
promote adequate sleep and other healthy lifestyles. "

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