Did you know? Sleep Respiratory Disorders Associated with an Acceleration of Epigenetic Age

Washington: The increase in the severity of respiratory disorders and sleep disturbances is badociated with an acceleration of epigenetic age, as indicated by recent findings. The study shows that each standard deviation increase in the apnea-hypopnea index, a measure of the severity of sleep-disordered breathing, was badociated with the equivalent of 215 days of ## EQU1 ## 39, biological acceleration of age. Likewise, each standard deviation of the wakefulness index, a measure of sleep disturbance, was badociated with the equivalent of 321 days of acceleration of the 39; age.

"The biological age of the people may not be the same as their chronological age.Individuals, whose biological age is greater than their chronological age, exhibit an accelerating age. age or rapid aging.Our data provide biological evidence to support the physiological and adverse health effects of untreated sleep-breathing disorders, "said lead author Xiaoyu Li.

The results of the study were published in the Journal of Sleep. Respiratory sleep disorders, such as obstructive sleep apnea, are characterized by abnormal breathing during sleep. Episodes often result in a reduction of oxygen saturation in the blood and usually end with brief awakenings during sleep. In the United States, nearly 30 million adults suffer from obstructive sleep apnea. Common warning signs include snoring and excessive daytime sleepiness.

According to the authors, epigenetic age acceleration is a marker of rapid biological aging based on DNA methylation and is badociated with modifiable lifestyle factors. Although sleep-disordered breathing is badociated with multiple age-related health disorders, its relationship to epigenetic aging has not been well studied.

Another surprising finding was that badociations were stronger in women than in men, suggesting that women may be particularly vulnerable to the adverse effects of sleep-disordered breathing.

"While women are often considered to pose a lower health risk as a result of sleep-disordered breathing, our findings suggest increased biological susceptibility," Li said.