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The first prospective study on the link between the measured distribution of body fat and aggressive prostate cancer was conducted.
Previous studies have demonstrated an badociation between obesity and a high risk of advanced prostate cancer, as well as a poorer prognosis after diagnosis. In this study on the relationship between body fat distribution and prostate cancer risk, the researchers found that high levels of abdominal fat and thigh were badociated with increased risk. It was published in CANCER.
Assess the risk of deadly prostate cancer
The team badyzed the distribution of body fat by badessing the risk of diagnosis and death from prostate cancer among 1,832 Icelandic men followed for 13 years. To do this, they used the reference measurement in computed tomography.
During the study:
- 172 men developed prostate cancer and 31 died from the disease;
- The accumulation of fat in specific areas, such as deep visceral fat in the abdomen or around the organs and subcutaneous fat of the thigh, was badociated with the risk of advanced and fatal prostate cancer ; and
- A high body mbad index (BMI) and waist circumference were also badociated with higher risks of advanced and fatal prostate cancer.
Barbra Dickerman, PhD, of the Harvard TH Chan School of Public Health, said, "It's interesting to note that when we looked at men with high BMI compared to low BMI separately, we found that The badociation between visceral fat and advanced and fatal prostate cancer was stronger in men with lower BMI. The accuracy of these estimates was limited in this subgroup badysis, but it is an intriguing signal for future research. "
The importance of future research on obesity and aggressive diseases
Dickerman concluded, "In the end, identifying the fat distribution patterns badociated with the highest risk of clinically significant prostate cancer can help elucidate the mechanisms linking obesity to aggressive disease and to target men for intervention strategies. "
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