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An inexpensive acne medication could protect millions of people from deadly heart disease by preventing the deadly hardening of the arteries.
It could also reduce the risk of the second most common form of dementia, which affects about 150,000 Britons.
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In a 12-year study, researchers at Cambridge University and King's College London revealed the causes of hardening of the arteries.
This disease causes the formation of stubborn calcium deposits, leaving the key vessels rigid and limiting blood flow to surrounding organs and tissues.
It increases the risk of cardiovascular disease, stroke and vascular dementia. Currently, there is no treatment.
But in laboratory tests on rats, scientists have successfully used an acne drug called minocycline consumed 22 times a day to prevent this deadly build-up.
They now hope to test the approach in humans before 2021.
Professor Melinda Duer of Cambridge University said: "We have absolutely no hope of finding a cure – there is currently no treatment and no one would have believed us if we had said at that time that we are going to remedy the hardening of the treatment. The arteries. "
JUST 22P PER DAY
Researchers have identified that a molecule responsible for repairing DNA in cells, called PAR, was at the origin of hardening of the arteries.
With the help of a chemical badysis, they discovered that he was released by the cells when they became stressed and died. It then binds to calcium in the blood before sticking to the artery walls and solidifying.
Professor Cathy Shanahan from King's College London said, "This hardening, or biomineralization, is essential for bone production, but in the arteries, it is at the root of many cardiovascular diseases and other diseases related to aging. like dementia. "
The results were published in the journal Cell Reports.
Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, which partially funded the study, said: "Calcification of blood vessels is a well-known risk factor for many heart and circulatory diseases, and can lead with hypertension, a life-threatening heart attack.
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"Now, researchers have shown how the calcification of blood vessel walls occurs and how this process differs from normal bone formation.
"In doing so, they were able to identify a potential treatment to reduce the calcification of blood vessels without any adverse effects on the bones.
"This type of treatment would benefit many people and we look forward to the results of the anticipated clinical trials to determine if this drug is keeping its promises."
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