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The researchers hope that young people's blood may hold the key to a longer life after discovering that a substance circulating in the veins of juvenile mice delays death and keeps the disease at bay.
US researchers, led by the University of Washington, discovered that a compound abundant in the blood of young mice, an enzyme known as eNampt, had extended their duration by 16%. life when it was transferred to older rodents.
"We have found a totally new path to healthy aging," said Dr. Shin-ichiro Imai, lead author of the study, published in the journal Cell.
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"The fact that we can take eNampt into the blood of young mice and give it to older mice and find that older mice show significant improvements in their health, including increased physical activity and better sleep – is remarkable. "
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The researchers administered each group of mice an oral dose of the enzyme or a saline control. The differences were "spectacular" between the groups.
The treated animals produced insulin more efficiently, had healthier eyes, had better memory test results, spent more time on their wheel, and became "thicker, brighter," the authors said. .
While no group in the control group lived beyond 2.4 years, one of the mice treated with eNampt was still alive at the time of writing the document – 2.8 years later.
This extra life could be directly predicted by measuring the levels of eNampt in the blood.
The results could offer another promising lead in a wave of research on "anti-senolytic" treatments.
These are intended to clean up old "zombie cells" that may contribute to old age conditions such as vision loss, heart disease, diabetes and cancer.
Because it is so fundamental to every living being, evolution has developed a multitude of supporting processes to ensure the proper levels of ingredients needed to turn sugars and oxygen into an energy molecule. ATP.
In the case of eNampt, it helps produce a chemical called NAD that is part of this cycle. Although the effects of eNampt have not yet been studied in humans, trials in humans are already under way for another chemical that plays a similar role and helps to rejuvenate the construction of new blood vessels.
"We believe that the body has so many redundant systems to maintain appropriate NAD levels because it is so important," Dr. Imai said.
"Our work and the work of others suggest that it governs the length of our lives and our health as we get older. Knowing that NAD inevitably decreases with age, whether worms, fruit flies, mice or humans, many researchers want to find anti-aging interventions to maintain NAD levels with aging. "
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